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. 2013 Apr 12;169(1):90–101. doi: 10.1111/bph.12110

Figure 9.

Figure 9

IL-33/ST2 mediates carrageenin-induced hyperalgesia via PGE2. Mice were treated with indomethacin (COX inhibitor, 5 mg·kg−1), 40 min, panels A and B) before IL-33 (100 ng·per paw) injection. Mechanical hyperalgesia was measured 3h (panel A) and 5 h (panel B) after IL-33 injection. Carrageenin (100 μg) or saline was injected i.pl. in ST2+/+ and ST2−/− mice and samples of cutaneous tissue were collected after 2 h for PGE2 levels determination by RIA (panel C). n = 6, representative of two separated experiments. *P < 0.05 compared with the saline group and #P < 0.05 compared with the IL-33 or carrageenin ST2+/+ group.