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MPP+ alters the activation kinetics of Ih in a voltage-dependent manner. (A) Ih currents elicited at −95, −115 and −135 mV evoked in control and after MPP+ 50 μM are shown. Fits are shown in magenta. Stimulation protocol is indicated in each panel. (B) Effect of MPP+ on tFAST (blue) and tSLOW (red) obtained at −95 (triangle), −115 (circle) and −135 mV (square) in control conditions and in MPP+ (n = 8). CTRL, control.
