Figure 9.
Inhibitory effect cannabichromene (CBC) on serum FICT-dextran concentration (a measure of intestinal barrier function) (A) and myeloperoxidase (MPO, a marker of intestinal inflammation) activity (B) in dinitrobenzene (DNBS)-induced colitis in mice. Permeability and MPO activity were measured on colonic tissues 3 days after vehicle or DNBS (150 mg·kg−1, intracolonically). CBC (1 mg·kg−1) was administered (i.p.) for 2 consecutive days starting 24 h after the inflammatory insult. Bars are mean ± SEM of five mice for each experimental group. #P < 0.001 versus control; *P < 0.05 and **P < 0.01 versus DNBS alone.