Table A1.

Associations between count of adverse events in childhood and CRP (mg/L) and IL-6 (pg/mL) at 10 years and CRP (mg/L) at 15 years.^a

Timing of adverse events	Age 10 Log CRPb			Age 10 Log IL-6b
	β	SE	p-value	β	SE	p-value
1.5 years	0.02	(0.03)	0.64	−0.01	(0.02)	0.80
2.5 years	0.02	(0.03)	0.47	0.01	(0.02)	0.66
3.5 years	0.02	(0.03)	0.50	0.00	(0.02)	0.84
4.5 years	0.01	(0.04)	0.75	0.01	(0.03)	0.72
6 years	0.05	(0.04)	0.21	0.04	(0.03)	0.21
7 years	0.10	(0.05)	0.03	0.15	(0.03)	<.0001
8 years	0.10	(0.04)	0.03	0.11	(0.03)	0.001
Sum scorec	0.03	(0.01)	0.02	0.01	(0.01)	0.10

	Age 15 Log CRP d			Age 15 Log CRP adjusted for Age10 CRP d
	β	SE	p-value	β	SE	p-value
1.5 years	0.10	(0.04)	0.01	0.07	(0.04)	0.09
2.5 years	0.02	(0.04)	0.55	0.03	(0.04)	0.47
3.5 years	0.06	(0.04)	0.11	0.06	(0.04)	0.17
4.5 years	0.04	(0.04)	0.36	0.03	(0.05)	0.54
6 years	−0.05	(0.04)	0.19	−0.09	(0.05)	0.06
7 years	0.02	(0.05)	0.66	−0.01	(0.06)	0.90
8 years	0.10	(0.05)	0.04	0.13	(0.06)	0.02
Sum scorec	0.02	(0.01)	0.13	0.02	(0.01)	0.18

Note: In the models not adjusted for age 10 CRP, the sample sizes in the baseline models range from N = 2802 (for the model of adverse events at 1.5 years) to N = 2047 (for the model using the summary score). In models adjusted for age 10 CRP, the samples sizes in the baseline models range from N = 1888 (model of adverse events at 1.5 years) to N = 1427 (model using the summary score).

^aLinear regression coefficients; models adjusted for gender, age at blood collection, ethnicity, family income at age 8 (5 categories + missing category), mother’s education at gestation (4-categories + missing category), medication at blood collection. Coefficients estimated in separate models.

^bFor the age 10 outcomes, the sample sizes in the baseline models range from N = 4126 (for the model of adverse events at 1.5 years) to N = 2895 (for the model using the summary score which requires data from all 7 time points).

^cSum of adverse events, collapsing measures between 1.5 and 8 years.