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. Author manuscript; available in PMC: 2014 Jun 1.
Published in final edited form as: Neurobiol Aging. 2013 Jan 9;34(6):1581–1588. doi: 10.1016/j.neurobiolaging.2012.12.005

Fig. 2.

Fig. 2

NR-treated slices from Tg2576 mice improves synaptic function but has no effect on WT mice. (A) Application of NR at 20 µM for 4 hours in hippocampal slices from Tg2576 mice (12–14-month-old) has no significantly effects on basal synaptic transmission recorded in CA1 region (A) (p > 0.05), however, the deficits of LTP in the Tg2576 mice was greatly rescued, n = 8 slices, 2-way analysis of variance; p < 0.01 (B). Perfusion of NR has no effects on the basal synaptic transmission (C) nor on the LTP (D) in hippocampal slices from WT littermates (n = 8, 2-way analysis of variance; p > 0.05). Abbreviations: fEPSP, field excitatory postsynaptic potentials; LTP, long-term potentiation; NR, nicotinamide riboside; WT, wild type.