Pregabalin reverses elevated depolarization-induced vasoconstriction in hypertension. A, Representative traces illustrating diameter responses to increasing extracellular K+. B, Pregabalin (24 h, 100 μmol/L) reduced depolarization (20, 40, and 60 mmol/L K+)-induced vasoconstriction more so in arteries from hypertensive rats than controls. Mean data (n: WKY, 6; WKY + pregabalin, 6; SHR, 6; SHR + pregabalin, 6). * indicates P<0.05 when compared with untreated WKY, and # indicates P<0.05 for SHR + pregabalin when compared with untreated SHR.