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. Author manuscript; available in PMC: 2014 Mar 6.
Published in final edited form as: Neuron. 2013 Mar 6;77(5):942–954. doi: 10.1016/j.neuron.2012.12.034

Figure 1. Stress blocks LTPGABA; forskolin can still potentiate GABAergic synapses.

Figure 1

(A), Single experiment illustrating SNAP-induced LTPGABA in a dopamine cell from a naïve animal, or (B) from an animal exposed to five min cold water forced swim. SNAP was bath-applied as indicated by the bar. (C), LTPGABA in slices from naïve or stressed animals (IPSC amplitudes, naïve rats: 128.2 ± 7.9% of control values, n = 3, 24 hours after stress, 95.4 ± 2.0%, n = 3; p < 0.05). (D), Single experiment illustrating forskolin-induced LTPGABA in slices from naïve animals or (E), in slices from animals exposed to forced swim stress. Forskolin (10 μM) was bath-applied as indicated by the bar. (F), Averaged data showing that forskolin potentiates IPSCs in dopamine neurons from naive and stressed animals. Insets: IPSCs before (Control) and 30 minutes after drug application (SNAP, 400 μM). Scale bars: 20 ms, 100 pA. Insets for this and all figures are averages of ten IPCSs.