Skip to main content
. Author manuscript; available in PMC: 2014 Mar 6.
Published in final edited form as: Neuron. 2013 Mar 6;77(5):942–954. doi: 10.1016/j.neuron.2012.12.034

Figure 2. Blocking KORs rescues the stress-induced block of LTPGABA.

Figure 2

(A), Injection protocol for naloxone treated animals. (B) LTPGABA in a dopamine cell from an animal administered saline 15 minutes prior to swim stress; slices were prepared 24 hrs after stress. Insets, representative IPSCs before (Control) and 30 minutes after SNAP application (SNAP). (C) Rescue of SNAP-induced LTPGABA in a slice from an animal treated with naloxone prior to stress. (D) Averaged experiments (saline-treated rats, n = 17; naloxone-treated rats, n = 9). (E) Injection protocol for nor-BNI treated animals; nor-BNI is effective for over a week following injection (Endoh et al., 1992). (F) Absence of LTPGABA in a dopamine cell from an animal administered saline 24 hrs prior to stress and (G) from an animal pretreated with nor-BNI 24 hours prior to stress. (H) Averaged experiments (saline-treated rats, n = 8; nor-BNI-treated rats, n = 8). Scale bars: 20 ms, 100 pA.