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. Author manuscript; available in PMC: 2013 Apr 22.
Published in final edited form as: Bioorg Med Chem Lett. 2008 Aug 7;18(18):5111–5114. doi: 10.1016/j.bmcl.2008.07.129

Figure 3.

Figure 3

Effect of post injection of compound 8 on biodistribution of [11C]DTBZ in pancreas. PET scans were performed on anesthetized 12–14 week old Lewis male rats injected with radioligand [11C]DTBZ (0 min, 0.5–1.0μCi/gm body weight, specific activity > 2000 mCi/mole) and cold compound 8(30mins, 2mg/kg). The fraction of radioligand in pancreas relative to the total amount of injected was calculated and plotted versus time after injection. Error bars indicate SEM (n=3). The area under the curve (AUC) from thirty minutes to ninety was calculated by the trapezoidal rule for each experiment. The statistical significance of difference between the average AUC baseline and AUC Compound 3 was p >0.05 as calculated by the method of Student.