Table 2.

Effects of Sulfasalazine on Vascular Function

Vascular Function Variable	Before Sulfasalazine	After Sulfasalazine	Before Placebo	After Placebo	P*
Systolic blood pressure (mmHg)	135±18	140±18	138±15	138±22	0.54
Diastolic blood pressure (mmHg)	74±7	75±8	75±8	74±9	0.59
Heart Rate (bpm)	66±11	69±12	66±11	65±10	0.06
Flow-mediated dilation (%)	6.8±4.0	7.5±3.9	7.2±3.6	7.4±4.2	0.83
Baseline diameter (mm)	4.80±0.82	4.85±0.83	4.82±0.77	4.88±0.81	0.99
Dilation to nitroglycerin (%)	9.0±6.2	9.2±5.6	8.4±5.8	10.8±7.0	0.11
Hyperemic flow (ml/min)	1669±1526	1517±622	1547±621	1424±508	0.16
PAT ratio (au)	1.52±1.03	1.80±1.29	1.54±0.72	1.82±1.04	0.98
lnPAT ratio (au)	0.29±0.44	0.43±0.53	0.35±0.38	0.48±0.46	0.61

Mean±SD.

^*P value for paired t-test comparing after sulfasalazine to after placebo