Table 3.
Effects of Sulfasalazine on Biochemical Profile
| Blood Marker | Before Sulfasalazine | After Sulfasalazine | Before Placebo | After Placebo | P* |
|---|---|---|---|---|---|
| Total Cholesterol (mg/dl) | 157±37 | 166±37 | 159±38 | 162±35 | 0.25 |
| LDL Cholesterol (mg/dl) | 81±30 | 94±31 | 83±34 | 89±29 | 0.09 |
| HDL Cholesterol (mg/dl) | 41±8 | 42±7 | 43±9 | 42±8 | 0.98 |
| Triglycerides (mg/dl) | 171±111 | 151±66 | 167±105 | 164±114 | 0.48 |
| Glucose (mg/dl) | 123±60 | 128±68 | 131±62 | 129±56 | 0.80 |
| Insulin (μIU/dl) | 13.0±8.1 | 10.7±5.0 | 13.2±9.3 | 11.9±5.4 | 0.25 |
| HOMA-IR(au) | 3.9±2.6 | 3.3±1.9 | 4.5±4.1 | 3.8±2.5 | 0.18 |
| C-reactive protein (mg/L) | 5.4±13.2 | 5.2±10.9 | 3.5±6.3 | 2.3±1.9 | 0.16 |
| P-selectin | 56±11 | 53±13 | 59±19 | 55±14 | 0.44 |
| Interleukin-6 | 2.7±2.0 | 2.6±1.8 | 2.5±1.5 | 2.6±2.0 | 0.99 |
| MCP-1 | 365±120 | 374±139 | 375±113 | 366±115 | 0.58 |
| Soluble-ICAM-1 | 272±72 | 283±82 | 293±84 | 281±90 | 0.85 |
Mean±SD.
*
P value for paired t-test comparing after sulfasalazine to after placebo HOMA-IR = Homeostasis model assessment of insulin resistance; ICAM-1 = intercellular adhesion molecule-1.