Figure 7.

At the top: Contact map of protein L.¹⁶³ The blue squares indicate residues that are in contact in the native state. The structure of the native state (PDB: 2PTL) is shown at the bottom-left of the figure. Data for the contact map were generated using the CMA server at http://ligin.weizmann.ac.il/cma/). The grey scale contour map shows the average distances (0–2 nm) between all pairs of residues at 300 K as simulated by Voelz et al.¹⁶³ The red dots indicate the contact map for one of the conformations of the unfolded state from the simulation. The structure of this state is shown at the bottom-right of the figure. Clearly this unfolded state is not a random coil but a partially structured non-native conformation.