Table 2.
Quantitative analysis of PROs in toxicity
|
Grade of PRO in toxicity |
Entity |
||||
|---|---|---|---|---|---|
| CRC | Non-CRC | u-GI | NSCLC | SCCHN | |
|
Stomatitis |
n= 57 |
n= 75 |
n=45 |
n=18 |
n=12 |
| None |
35.1% |
61.3% |
66.7% |
66.7% |
33.4% |
| Grade 1/2 |
54.4% |
32.0% |
31.1% |
27.8% |
41.6% |
| Grade 3/4 |
10.5% |
6.7% |
2.2% |
5.5% |
25.0% |
|
Nausea |
n=54 |
n=70 |
n=44 |
n=14 |
n=12 |
| None |
44.4% |
21.4% |
18.2% |
21.5% |
33.4% |
| Grade 1/2 |
50.0% |
68.6% |
72.8% |
71.4% |
50.0% |
| Grade 3/4 |
5.6% |
10.0% |
9.0% |
7.1% |
16.6% |
|
Emesis |
n=54 |
n=74 |
n=42 |
n=18 |
n=13 |
| None |
81.4% |
75.7% |
76.2% |
72.3% |
77.0% |
| Grade 1/2 |
16.7% |
24.3% |
23.8% |
27.7% |
23.0% |
| Grade 3/4 |
1.9% |
0.0% |
0.0% |
0.0% |
0.0% |
|
Diarrhea |
n=56 |
n=74 |
n=44 |
n=17 |
n=13 |
| None |
35.7% |
62.1% |
54.6% |
76.5% |
69.3% |
| Grade 1/2 |
50.0% |
33.8% |
38.6% |
23.5% |
30.7% |
| Grade 3/4 |
14.3% |
4.1% |
6.8% |
0.0% |
0.0% |
|
Fatigue |
n=57 |
n=76 |
n=45 |
n=18 |
n=13 |
| None |
7.0% |
6.6% |
6.7% |
5.6% |
7.7% |
| Grade 1/2 |
87.7% |
81.6% |
75.6% |
94.4% |
84.6% |
| Grade 3/4 |
5.3% |
11.8% |
17.7% |
0.0% |
7.7% |
|
Sens. Neu. |
n=55 |
n=74 |
n=44 |
n=17 |
n=13 |
| None |
40.0% |
36.5% |
31.9% |
41.2% |
46.1% |
| Grade 1/2 |
65.4% |
56.7% |
59.1% |
58.8% |
46.1% |
| Grade 3/4 |
3.6% |
6.8% |
9.0% |
0.0% |
7.8% |
|
Skin toxicity |
n=58 |
n=75 |
n=45 |
n=17 |
n=13 |
| None |
57.0% |
64.0% |
73.4% |
64.8% |
30.8% |
| Grade 1/2 |
27.5% |
25.4% |
24.4% |
11.7% |
46.1% |
| Grade 3/4 |
15.5% |
10.6% |
2.2% |
23.5% |
23.0% |
|
Alopecia |
n=56 |
n=73 |
n=45 |
n=16 |
n=12 |
| None |
33.9% |
24.6% |
26.7% |
18.75% |
25.0% |
| Grade1 |
53.6% |
56.2% |
60.0% |
50.0% |
50.0% |
| Grade 2 | 12.5% | 19.2% | 13.3% | 31.25% | 25.0% |
Sens. Neu. = Sensory Neuropathy.