Table 3.
Outcome measures of effectiveness in patients with combined treatment or medication treatment
| Outcome | Combined treatment (n=604) |
Medication treatment (n=635) |
p value |
|---|---|---|---|
| Discontinuation of treatment for any cause No. (%) | 198(32.8%) | 297 (46.8%) | |
| Cox–model treatment comparisons (HR[95%CI]) | 0.62(0.52—0.74) | <0.001 | |
| Discontinuation of treatment for any causea No. (%) | 176(29.1%) | 269(42.4%) | |
| Cox–model treatment comparisons (HR[95%CI]) | 0.57(0.46—0.70) | <0.001 | |
| Discontinuation of treatment due to clinical relapse No. (%) | 88(14.6%) | 143(22.5%) | |
| Cox–model treatment comparisons (HR[95%CI]) | 0.57(0.44—0.74) | <0.001 | |
| Discontinuation of treatment for lost to follow-up or patient’s refusal No. (%) | 71(11.8%) | 90(14.2%) | |
| Cox–model treatment comparisons (HR[95%CI]) | 0.74(0.54—1.01) | 0.054 | |
| Discontinuation of treatment for noncompliance No. (%) | 17(2.8%) | 36(5.7%) | |
| Cox–model treatment comparisons (HR[95%CI]) | 0.45(0.25—0.79) | 0.006 | |
| Discontinuation of treatment for changing or stopping medication No. (%) | 17(2.8%) | 19(3.0%) | |
| Cox–model treatment comparisons (HR[95%CI]) | 0.84(0.44—1.62) | 0.60 | |
| Discontinuation of treatment due to intolerability No. (%) | 5(0.8%) | 9(1.4%) | |
| Cox–model treatment comparisons (HR[95%CI]) | 0.66(0.22—1.99) | 0.46 | |
| Discontinuation of treatment due to readmission No. (%) | 39(6.5%) | 71(11.2%) | |
| Cox–model treatment comparisons (HR[95%CI]) | 0.50(0.34—0.74) | 0.007 | |
Abbreviation: HR, hazard ratios; CI, confidence interval;
a
excluding those discontinued due to change of medication or intolerability