Table 1. Patient characteristics.

Patient no.	Sex	Age at TX	Diagnosis	Donor	Source	Conditioning	GVHD prophylaxis	PCR-positive results in stool, first and last day	highest PCR-positive results in stool, copies/g	PCR-positive results in blood, first and last day	HAdV strain	Antiviral treatment	CD3+ >50/µl post TX, day	Detection of ADV-specific T cells during ADV-clearance, yes/no	Detection of ADV-specific T cells after ADV-clearance, yes/no	Status at month 6 post TX concerning ADV infection
1	w	19	T-ALL	FD, haplo, m T cell depletion	PBSC	Flu/VP16/OKT3	mmf	day 102–272	5×10E7	day 109–110, 6×10E5	C	Cidofovir	between day 34–41	no	yes	died after Heart TX, no ADV infection
2	m	2	M Kostmann	MUD, m	BM	Flu/Thio/Mel/ATG	CyA, mmf	day 21–260	2×10E7	not positive	C	Cidofovir	between day 14–21	no	yes	still alive, no ADV infection
3	w	3	MHC II Deficiency	MFD, f	BM	Flu/Thio/Mel/ATG	CyA, mmf	day –15–75	1×10E10	day 13–27, 1×10E4	C	Cidofovir + Ribavirin	between day 13–20	no	yes	still alive, no ADV infection
4	w	8	NBL Rez.	FD, haplo, m T cell depletion	PBSC	Flu/Thio/Mel/OKT3	CyA	day 106–252	1×10E6	not positive	C	none	between day 27–41	not determined	yes	still alive, no ADV infection
5	m	12	ALL Rez.	MUD, m	BM + Boost (day154)	TBI/VP16/ATG	CyA, MTX	day 21–181	2×10E10	day 27–49, 1×10E3	A and C	Cidofovir	between day 28–34	not determined	yes	still alive, no ADV infection
6	m	5	Sept Granulomatose	MFD, f	BM	Flu/Thio/Mel/ATG	CyA, mmf	day –11–92	2×10E5	not positive	C	none	between day 13–20	not determined	yes	still alive, no ADV infection
7	m	7	NBL IV	FD, haplo, f T cell depletion	PBSC	Flu/Thio/Mel/OKT3	CyA	day 6–118	5×10E7	not positive	B and C	Cidofovir	between day 34–42	not determined	yes	still alive, no ADV infection
8	w	3	Hyper IGE Syndrom	MUD, f	BM	Flu/Thio/Mel/ATG	CyA, mmf	day 5–13	1×10E4	not positive	C	Gancyclovir	between day 13–16	not determined	yes	still alive, no ADV infection
9	m	5	Fanconi, MDS	MFD, f	BM	FLU/BU/ATG/Campath	CyA, mmf	day 11–281	9×10E6	not positive	A and C	Ribavirin	between day 14–18	not determined	yes	still alive, no ADV infection
10	m	6	C ALL Rez.	MUD, f	BM	TBI/VP16/ATG		day 54–61	7×10E3	not positive	C	none	between day 19–22	not determined	yes	still alive, no ADV infection

Patient No. 2 had transient enteritic symptoms attributed to clostridium difficile infection;

Patient No. 10 had transient enteritic symptoms attributed to gut GVHD.

GVHD, graft-versus-host disease; ALL, acute lymphoblastic leukemia; Rel, relapse; Morbus Kostmann, MHC II, major histocompatibility complex class II, NBL rel, Neuroblastoma relapse; Sept, septic granulomatous disease; NBL IV, Neuroblastoma grade IV; IGE, immunoglobulin E; MDS, myelodysplastic syndrome; common ALL, FD, family donor; haplo, haploidentical; MUD, matched unrelated donor; MFD, matched family donor; m, male; f, female; PBSC, peripheral blood stem cells; BM, bone marrow; Flu, fludarabine; VP16, Etoposide; ThioMel, Thiotepa Melphalan ATG, antithymocyte globulin; TBI, total body irradiation; mmf, mycophenolate mofetil; CyA, cyclophosphamide A; PCR, polymerase chain reaction; HAdV, adenovirus.