Table 1. Levels of amino acids in the frontal cortex and cerebellum 24 hours after the last administration of Met-Phen.

	Glutamate	Glutamine	Glycine	L-Serine	D-Serine
Frontal cortex
Control	4.729±0.294	3.649±0.373	1.892±0.442	0.746±0.036	0.150±0.005
Met-Phen	5.857±0.314 (124%)*	4.371±0.141 (120%)*	1.463±0.369 (77.3%)	0.585±0.019 (78.4%)***	0.130±0.004 (86.7%)*
Cerebellum
Control	3.509±0.220	7.118±0.298	2.602±0.153	0.848±0.034	0.154±0.006
Met-Phen	4.375±0.221 (125%)*	9.200±0.423 (129%)**	2.294±0.153 (88.2%)	0.827±0.039 (97.5%)	0.125±0.006 (81.2%)*

Data (nmol/mg tissue) are expressed as the mean ± SEM (Control: n = 9, Met-Phen: n = 21).

Parenthesis is the percentage of control values.

^*p<0.05,

^**p<0.01,

^***p<0.001 compared to control group (Student’s t test).