Figure 4. AID^−/− B cells accumulate normally in the CNS.

WT and AID^−/− mice were immunized with recombinant human MOG (rhMOG) and spinal cords (A) and brains (B) were extracted and processed at day 15 (peak of disease). B cells and T cells were quantified by flow cytometry. Although the frequency of B cells was observed to be greater in AID^−/− mice, the absolute numbers of B cells was unaffected. In contrast, T cell frequency and numbers were reduced in the spinal cord. This experiment was performed twice with similar results and 8–12 mice per group were tested.