Table 4. The hypotensive effects of α,β-ADR blockers between KCNH2(C1966T) genotypes(CC v.s CT+TT) and age(≤55 y v.s 55 y), gender(Men v.s Women)interactions in EH patients.

Drugs	Variables(n)	P-value*			Partial Eta Squared			Observed Power
		gene* gender	gene* age	gene* age* gender	gene* gender	gene* age	gene* age* gender	gene* gender	gene* age	gene* age* gender
doxazosin	ΔDBP6(36)	0.010	0.017	0.027	0.357	0.324	0.416	0.862	0.812	0.821
	ΔMAP6(36)	0.047	0.027	0.036	0.261	0.298	0.401	0.283	0.758	0.791
celiprolol, bisoprolol or atenolol	ΔHR4(91)	<0.001	0.028	0.013	0.267	0.118	0.205	0.997	0.756	0.90
	ΔDBP4(91)	<0.001	0.005	0.002	0.26	0.150	0.254	0.99	0.88	0.971
	ΔMAP4(91)	<0.001	0.030	0.024	0.214	0.116	0.187	0.979	0.749	0.861
doxazosin or celiprolol	ΔDBP6 (89)	0.053	0.054	0.019	0.104	0.104	0.198	0.676	0.675	0.877
	ΔMAP6(89)	0.055	0.165	0.078	0.103	0.074	0.157	0.671	0.492	0.748
doxazosin, bisoprolol or atenolol	ΔHR4(120)	0.023	0.034	0.043	0.095	0.087	0.133	0.778	0.734	0.817
	ΔDBP4(120)	0.002	0.012	0.016	0.141	0.100	0.154	0.94	0.836	0.890
	ΔMAP4(120)	0.007	0.027	0.053	0.115	0.092	0.128	0.870	0.760	0.797
doxazosin, cileprolol, bisoprolol or atenolol	ΔHR4(173)	0.009	0.120	0.093	0.078	0.043	0.079	0.854	0.555	0.739
	ΔDBP4(173	<0.001	0.005	0.007	0.120	0.085	0.124	0.982	0.930	0.892
	ΔMAP4(173)	0.002	0.019	0.035	0.100	0.068	0.096	0.941	0.838	0.793

^*P-values were with bonferroni adjust and BMI, gender ,age adjust were appropriately use in the model,ΔHR4 = heart rate change at the end of 4 weeks, ΔDBP4 = diastolic pressure change at the at the end of 4 weeks,ΔMAP4 = mean arterial pressure change at the at the end of 4 weeks,ΔDBP6 = diastolic pressure change at the end of 6weeks, ΔMAP6 = mean arterial pressure change at the end of 6 weeks.