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. 2013 Apr 22;8(4):e61416. doi: 10.1371/journal.pone.0061416

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© 2013 Chaowanachan et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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(A) Scanning electron photomicrographs (magnification, 15,000×) of nanoparticles encapsulated with antiretroviral drugs efavirenz (NP-EFV) or saquinavir (NP-SQV). (B) Fourier transform infrared spectroscopy (FTIR) confirmation of the antiretroviral drugs loaded into PLGA nanoparticles. Insets show characteristic frequencies of SQV and EFV and the PLGA polymer (Vehicle Control). (C) HPLC chromatograms of vehicle control (black), SQV (blue) and EFV (red) nanoparticles showing the detection of SQV and EFV only in ARV loaded nanoparticles. No drug peak was detected in the vehicle control nanoparticles. (D) Cumulative release of EFV and SQV from nanoparticles in a vaginal fluid simulant (VFS) showing the release of SQV and EFV over 24 h.