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. 2013 Apr 22;8(4):e61416. doi: 10.1371/journal.pone.0061416

Figure 3. PLGA nanoparticles loaded with EFV or SQV show low cytotoxity.

Figure 3

Viability of TZM-bl cells measured by the CellTiter-Blue™ (Promega) viability assay demonstrating non-toxic concentrations (>80% viability) of efavirenz nanoparticles (NP-EFV) and saquinavir nanoparticles (NP-SQV) at ≤1,000 µg of polymer/mL (≤48 µM EFV and ≤26 µM SQV). Vehicle control nanoparticles at the concentrations tested showed no reduction of viability (100%±8%), indicating non-cytotoxicity of PLGA polymer. Negative control = media only, Positive control = DMSO. *Vehicle control for NP-SQV was measured at 10,000 µg of polymer/mL.