Table 2. Human/mouse β-Klotho chimeras used to determine Avimer binding site.
Chimera | Primary Structure |
1 | 1-F519 (Mouse)::P522-S1044 (Human) |
2 | 1-F521 (Human)::P520-S1043 (Mouse) |
3 | 1-F82 (Human)::P83-G301 (Mouse)::S302-S1044 (Human) |
4 | 1-L193 (Human)::Y194-N415 (Mouse)::G418-S1044 (Human) |
5 | 1-G301 (Human)::S302-F506 (Mouse)::S509-S1044 (Human) |
6 | 1-N417 (Human)::G416-F519 (Mouse)::P522-S1044 (Human) |
7 | 1-F506 (Human)::G507-G632 (Mouse)::L635-S1044 (Human) |
8 | 1-F521 (Human)::P520-A735 (Mouse)::V738-S1044 (Human) |
9 | 1-L633 (Human)::G632-Q849 (Mouse)::D852-S1044 (Human) |
10 | 1-G736 (Human)::A735-S963 (Mouse)::G967-S1044 (Human) |