Table 1. Selection of meta-analyses of cohorts without pre-existing cardiovascular disease on markers for cardiovascular disease risk.

Marker	Risk Applies To	Risk	Results	95% ci	N Patients	N Cohorts	Reference
Diabetes related
Glucose post load	Above: 7.8 mmol/L	RR	1.58	1.19–2.10	1,467 cases	7	[31]
Glycated hemoglobine (HBA(1c))	HbA1c level: 0.7	RR	1.58	1.22–2.06	1,366 cases	7	[32]
Hemostasis
Fibrinogen	1 g/L increase	HR	2.33	1.91–2.84	992 cases	31	[5]
Fibrinogen	1 g/L increase	HR	1.93	1.79–2.08	7,118 cases	31	[5]
Hormones
Vitamin D (serum 25-OH D)	Decrease in different predefined categories	HR	1.83	1.19–2.80	2,007 cases	5	[9]
Vitamin D (serum 25-OH D)	Decrease in different predefined categories	HR	1.54	1.22–1.95	756 cases	4	[9]
Inflammation
CRP1	Top vs bottom tertile	RR	2.43	2.10–2.83	3,181 cases	12	[6]
CRP	Top vs bottom tertile	OR	1.58	1.48–1.68	7,068 cases	22	[33]
Lipids
ApoB2	Top vs bottom tertile	RR	1.99	1.65–2.39	6,920 cases	19	[7]
ApoB/ApoAI ratio	Top vs bottom tertile	RR	1.86	1.55–2.22	3.730 cases	7	[7]
HDL3	0.33 mmol/L decrease	HR	1.83	1.65–2.03	1,198 cases	23	[8]
Triglycerides	Top vs bottom tertile	OR	1.72	1.56–1.90	10,158 cases	29	[34]
HDL	0.33 mmol/L decrease	HR	1.63	1.44–1.85	764 cases	23	[8]
ApoAI	Bottom vs top tertile	RR	1.62	1.43–1.83	6,333 cases	21	[7]
Non-HDL cholesterol	43 mg/dL increase	HR	1.59	1.36–1.85	12,785 cases	68	[35]
ApoB	29 mg/dL increase	HR	1.58	1.39–1.79	4,499 cases	22	[35]
Non-HDL cholesterol	1.53 unit increase	HR	1.50	1.38–1.62	4,499 cases	22	[35]
Non-HDL cholesterol	1 mmol/L decrease	HR	0.66	0.61–0.71	1,198 cases	23	[8]
Cholesterol/HDL	1.33 units decrease	HR	0.60	0.56–0.64	1,198 cases	23	[8]
Cholesterol	1 mmol/L decrease	HR	0.58	0.56–0.61	5,561 cases	61	[8]
Non-HDL cholesterol	1 mmol/L decrease	HR	0.57	0.52–0.62	764 cases	23	[8]
Cholesterol/HDL	1.33 units decrease	HR	0.56	0.51–0.60	764 cases	23	[8]
Cholesterol	1 mmol/L decrease	HR	0.44	0.42–0.48	1,309 cases	61	[8]

¹CRP: C-reactive protein.

²Apo: apolipoprotein.

³HDL: high density lipoprotein.