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. Author manuscript; available in PMC: 2013 Apr 22.
Published in final edited form as: Discov Med. 2012 Feb;13(69):105–113.

Figure 1.

Figure 1

Structures of the human GLI1 gene and the encoded full-length GLI1, GLI1ΔN, and tGLI1 isoforms. The full-length GLI1 gene is comprised of 12 exons, including the 5′-untranslated exon 1. The GLI1 coding region spans nt +79 to +3399 with the initiating methionine codon, ATG, at +79 in exon 2 (arrows). Exons are indicated as gray boxes while introns are shown by lines. The known functional domains of full-length GLI1 include the degron degradation signals (Dn and Dc; aa 77–116; 464–469), SUFU-binding domains (SU; aa 111–125 and C-terminus) (Dunaeva et al., 2003), zinc finger domains (ZF; aa 235–387), the nuclear localization signal (NLS; aa 380–420), and the transactivation domain (aa 1020–1091). Alternative splicing of GLI1 RNA can lead to the deletion of exons 1–3 totaling 128 amino acids in the N-terminus, forming the GLI1ΔN variant. The deletion of the entire exon 3 and part of exon 4 totaling 41 amino acids yields the tGLI1 isoform. Notably, tGLI1 retains all the known functional domains of the full-length GLI1.