Fig. 6.

Formation of vessels arising via angiogenesis is perturbed in invadolysin morphant fish. Comparison of vascular formation in non-injected (A, C and E) and Ex6-MO injected (B, D and F) Tg(fli1:egfp) fish at 48 and 72 hpf. The dorsal aorta (DA) and posterior cardinal vein (PCV) formed through vasculogenesis appear normal in both non-injected and Ex6-MO injected fish. However, the inter-segmental vessels (Se) and parachordal vessels (PAV) generated by angiogenic sprouting are either poorly formed or absent in the Ex6-MO injected fish at 48 and 72 hpf (D and F, arrowheads). Scale bar=250 μm.