Table A1.
Anionic metabolites detected from cerebrum in GF mice and Ex-GF mice.
| ID | HMT DB† |
Relative area§ |
Comparative analysis |
|||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Compound name | KEGG ID | HMDB ID | Germ-free |
SPF |
Germ-free |
SPF |
SPF vs. Germ-free |
|||||||||
| GF1 | GF2 | GF3 | Ex-GF1 | Ex-GF2 | Ex-GF3 | Mean | SD | Mean | SD | Ratio1 | p-Value2 | |||||
| A_0052 | 2,3-Diphosphoglyceric acid | C01159 | HMDB01294 | 7.6E-05 | 6.7E-05 | 1.2E-04 | 1.5E-04 | 1.3E-04 | 2.0E-04 | 8.7E-05 | 2.7E-05 | 1.6E-04 | 4.0E-05 | 1.853 | 0.064 | |
| A_0007 | 2-Hydroxyisobutyric acid | – | HMDB00729 | 1.3E-04 | 1.6E-04 | 1.8E-04 | 3.0E-04 | 2.2E-04 | 2.1E-04 | 1.6E-04 | 2.3E-05 | 2.4E-04 | 4.7E-05 | 1.525 | 0.073 | |
| A_0041 | Phosphocreatine | C02305 | HMDB01511 | 1.1E-04 | 1.1E-04 | 9.9E-05 | 1.8E-04 | 1.6E-04 | 1.1E-04 | 1.1E-04 | 7.2E-06 | 1.5E-04 | 3.5E-05 | 1.430 | 0.146 | |
| A_0015 | 5-Oxoproline | C01879 | HMDB00267 | 1.9E-03 | 1.0E-03 | 5.4E-04 | 2.5E-03 | 1.6E-03 | 7.5E-04 | 1.1E-03 | 6.9E-04 | 1.6E-03 | 8.6E-04 | 1.398 | 0.517 | |
| A_0088 | ADP-ribose | C00301 | HMDB01178 | 2.2E-04 | 2.3E-04 | 3.8E-04 | 2.6E-04 | 3.8E-04 | 4.1E-04 | 2.7E-04 | 9.0E-05 | 3.5E-04 | 7.8E-05 | 1.272 | 0.338 | |
| A_0044 | Ribose 5-phosphate | C00117 | HMDB01548 | 1.1E-04 | 1.1E-04 | 1.1E-04 | 1.3E-04 | 1.4E-04 | 1.2E-04 | 1.1E-04 | 3.2E-06 | 1.3E-04 | 9.1E-06 | 1.190 | 0.044 | * |
| A_0037 | Isocitric acid | C00311 | HMDB00193 | 1.1E-04 | 1.7E-04 | 1.2E-04 | 1.3E-04 | 1.5E-04 | 1.9E-04 | 1.3E-04 | 3.1E-05 | 1.6E-04 | 3.1E-05 | 1.189 | 0.377 | |
| A_0087 | GTP | C00044 | HMDB01273 | 4.1E-04 | 3.9E-04 | 5.3E-04 | 6.2E-04 | 4.7E-04 | 4.6E-04 | 4.5E-04 | 7.9E-05 | 5.2E-04 | 9.0E-05 | 1.167 | 0.345 | |
| A_0067 | NADPH_divalent | C00005 | HMDB00221 | 5.4E-05 | 7.7E-05 | 7.4E-05 | 8.5E-05 | 6.9E-05 | 8.5E-05 | 6.8E-05 | 1.2E-05 | 8.0E-05 | 9.4E-06 | 1.166 | 0.281 | |
| A_0013 | 2-Hydroxyvaleric acid | – | HMDB01863 | 1.5E-04 | 1.7E-04 | 1.1E-04 | 1.9E-04 | 1.3E-04 | 1.9E-04 | 1.5E-04 | 2.8E-05 | 1.7E-04 | 3.3E-05 | 1.162 | 0.397 | |
| A_0036 | Citric acid | C00158 | HMDB00094 | 6.3E-03 | 7.2E-03 | 6.3E-03 | 9.3E-03 | 5.7E-03 | 7.8E-03 | 6.6E-03 | 5.3E-04 | 7.6E-03 | 1.8E-03 | 1.153 | 0.433 | |
| A_0032 | Homovanillic acid | C05582 | HMDB00118 | 9.4E-05 | 1.6E-04 | 1.6E-04 | 1.5E-04 | 1.6E-04 | 1.5E-04 | 1.4E-04 | 3.8E-05 | 1.5E-04 | 5.1E-06 | 1.109 | 0.568 | |
| A_0048 | myo-Inositol 1-phosphate myo-Inositol 3-phosphate |
C01177 C04006 |
HMDB00213 HMDB06814 |
6.6E-04 | 6.0E-04 | 5.5E-04 | 7.3E-04 | 5.9E-04 | 6.7E-04 | 6.0E-04 | 5.8E-05 | 6.6E-04 | 6.7E-05 | 1.098 | 0.317 | |
| A_0025 | Uric acid | C00366 | HMDB00289 | 6.0E-05 | 7.8E-05 | 5.9E-05 | 6.3E-05 | 7.8E-05 | 6.9E-05 | 6.6E-05 | 1.1E-05 | 7.0E-05 | 7.9E-06 | 1.068 | 0.592 | |
| A_0074 | Acetyl CoA_divalent | C00024 | HMDB01206 | 5.5E-05 | 5.4E-05 | 4.6E-05 | 4.6E-05 | 5.6E-05 | 6.1E-05 | 5.2E-05 | 5.3E-06 | 5.4E-05 | 7.9E-06 | 1.048 | 0.677 | |
| A_0023 | 3-Hydroxy-3-methylglutaric acid | C03761 | - | 3.5E-04 | 3.1E-04 | 3.0E-04 | 3.6E-04 | 3.4E-04 | 3.1E-04 | 3.2E-04 | 2.3E-05 | 3.4E-04 | 2.4E-05 | 1.047 | 0.479 | |
| A_0077 | GDP | C00035 | HMDB01201 | 1.5E-03 | 1.7E-03 | 2.1E-03 | 1.9E-03 | 1.6E-03 | 2.0E-03 | 1.8E-03 | 3.1E-04 | 1.8E-03 | 2.3E-04 | 1.033 | 0.803 | |
| A_0093 | UDP-N-acetyl glucosamine | C00043 | HMDB00290 | 9.1E-04 | 1.0E-03 | 1.0E-03 | 1.1E-03 | 9.5E-04 | 9.9E-04 | 9.8E-04 | 6.5E-05 | 1.0E-03 | 8.3E-05 | 1.030 | 0.654 | |
| A_0056 | N-Acetyl glucosamine 6-phosphate | C00357 | HMDB01062 | 1.2E-04 | 9.6E-05 | 8.0E-05 | 1.3E-04 | 9.3E-05 | 7.4E-05 | 9.7E-05 | 1.8E-05 | 1.0E-04 | 3.0E-05 | 1.025 | 0.909 | |
| A_0083 | CDP-choline | C00307 | HMDB01413 | 2.0E-04 | 1.8E-04 | 2.6E-04 | 2.2E-04 | 1.8E-04 | 2.4E-04 | 2.1E-04 | 4.0E-05 | 2.1E-04 | 3.1E-05 | 1.012 | 0.935 | |
| A_0002 | Propionic acid | C00163 | HMDB00237 | 1.7E-04 | 9.9E-05 | 1.1E-04 | 1.4E-04 | 1.3E-04 | 1.0E-04 | 1.3E-04 | 4.0E-05 | 1.3E-04 | 2.1E-05 | 1.010 | 0.964 | |
| A_0092 | GDP-mannose GDP-galactose |
C00096 C02280 |
HMDB01163 - | 1.8E-04 | 2.2E-04 | 2.2E-04 | 2.1E-04 | 1.9E-04 | 2.4E-04 | 2.1E-04 | 2.3E-05 | 2.1E-04 | 2.4E-05 | 1.005 | 0.955 | |
| A_0017 | Malic acid | C00149, C00497, C00711 | HMDB00156, HMDB00744 | 1.5E-02 | 1.6E-02 | 1.5E-02 | 1.5E-02 | 1.3E-02 | 1.7E-02 | 1.5E-02 | 6.0E-04 | 1.5E-02 | 1.8E-03 | 1.001 | 0.992 | |
| A_0010 | Fumaric acid | C00122 | HMDB00134 | 1.9E-03 | 2.1E-03 | 1.9E-03 | 1.8E-03 | 1.7E-03 | 2.4E-03 | 2.0E-03 | 1.0E-04 | 2.0E-03 | 3.5E-04 | 0.997 | 0.977 | |
| A_0016 | N-Acetyl-β-alanine | C01073 | – | 5.8E-05 | 7.2E-05 | 6.8E-05 | 6.8E-05 | 6.1E-05 | 6.6E-05 | 6.6E-05 | 7.3E-06 | 6.5E-05 | 3.7E-06 | 0.987 | 0.870 | |
| A_0091 | ADP-glucose GDP-fucose |
C00498 C00325 |
HMDB06557 HMDB01095 |
8.2E-05 | 8.5E-05 | 8.9E-05 | 9.7E-05 | 7.9E-05 | 7.8E-05 | 8.6E-05 | 3.6E-06 | 8.5E-05 | 1.0E-05 | 0.987 | 0.873 | |
| A_0035 | N-Acetyl glutamic acid | C00624 | HMDB01138 | 7.1E-04 | 6.6E-04 | 6.4E-04 | 6.9E-04 | 6.6E-04 | 6.1E-04 | 6.7E-04 | 3.6E-05 | 6.5E-04 | 4.1E-05 | 0.981 | 0.714 | |
| A_0029 | cis-Aconitic acid | C00417 | HMDB00072 | 1.6E-04 | 2.8E-04 | 1.5E-04 | 1.6E-04 | 1.9E-04 | 2.3E-04 | 2.0E-04 | 7.3E-05 | 1.9E-04 | 3.3E-05 | 0.974 | 0.920 | |
| A_0043 | Ribulose 5-phosphate | C00199, C01101 | HMDB00618 | 2.5E-03 | 2.1E-03 | 1.7E-03 | 2.1E-03 | 2.3E-03 | 1.8E-03 | 2.1E-03 | 3.9E-04 | 2.1E-03 | 2.4E-04 | 0.969 | 0.817 | |
| A_0068 | CoA_divalent | C00010 | HMDB01423 | 4.1E-04 | 4.1E-04 | 4.4E-04 | 3.8E-04 | 3.8E-04 | 4.1E-04 | 4.2E-04 | 2.0E-05 | 3.9E-04 | 2.0E-05 | 0.927 | 0.138 | |
| A_0022 | Pelargonic acid | C01601 | HMDB00847 | 8.7E-05 | 5.5E-05 | 6.7E-05 | 5.3E-05 | 5.4E-05 | 8.7E-05 | 7.0E-05 | 1.6E-05 | 6.5E-05 | 1.9E-05 | 0.927 | 0.743 | |
| A_0006 | Lactic acid | C00186, C00256, C01432 | HMDB00190, HMDB01311 | 2.9E-01 | 2.8E-01 | 3.1E-01 | 2.7E-01 | 2.5E-01 | 3.0E-01 | 3.0E-01 | 1.3E-02 | 2.7E-01 | 2.7E-02 | 0.920 | 0.262 | |
| A_0094 | CMP-N-acetylneuraminate | C00128 | HMDB01176 | 4.7E-04 | 5.7E-04 | 5.2E-04 | 4.9E-04 | 5.4E-04 | 3.9E-04 | 5.2E-04 | 4.9E-05 | 4.7E-04 | 7.7E-05 | 0.919 | 0.481 | |
| A_0031 | Ascorbic acid | C00072 | HMDB00044 | 3.5E-02 | 3.5E-02 | 3.2E-02 | 3.3E-02 | 2.8E-02 | 3.3E-02 | 3.4E-02 | 1.6E-03 | 3.1E-02 | 3.0E-03 | 0.918 | 0.255 | |
| A_0061 | cAMP | C00575 | HMDB00058 | 2.7E-05 | 4.3E-05 | 3.5E-05 | 3.9E-05 | 2.3E-05 | 3.4E-05 | 3.5E-05 | 7.8E-06 | 3.2E-05 | 7.9E-06 | 0.916 | 0.667 | |
| A_0085 | ATP | C00002 | HMDB00538 | 1.1E-03 | 1.1E-03 | 1.0E-03 | 1.1E-03 | 1.0E-03 | 7.9E-04 | 1.1E-03 | 3.4E-05 | 9.7E-04 | 1.7E-04 | 0.915 | 0.455 | |
| A_0070 | FAD_divalent | C00016 | HMDB01248 | 5.9E-05 | 7.3E-05 | 7.6E-05 | 6.5E-05 | 6.3E-05 | 5.7E-05 | 6.9E-05 | 9.2E-06 | 6.2E-05 | 4.0E-06 | 0.890 | 0.288 | |
| A_0090 | UDP-glucuronic acid | C00167 | HMDB00935 | 1.2E-04 | 1.4E-04 | 1.2E-04 | 1.1E-04 | 1.1E-04 | 1.2E-04 | 1.2E-04 | 1.3E-05 | 1.1E-04 | 4.9E-06 | 0.879 | 0.172 | |
| A_0051 | Glucose 1-phosphate | C00103 | HMDB01586 | 1.5E-04 | 2.0E-04 | 2.0E-04 | 1.8E-04 | 1.3E-04 | 1.7E-04 | 1.8E-04 | 2.9E-05 | 1.6E-04 | 2.3E-05 | 0.869 | 0.328 | |
| A_0018 | Threonic acid | C01620 | HMDB00943 | 1.2E-03 | 1.4E-03 | 1.3E-03 | 1.3E-03 | 1.0E-03 | 1.1E-03 | 1.3E-03 | 8.1E-05 | 1.1E-03 | 1.8E-04 | 0.860 | 0.211 | |
| A_0057 | N-Acetylneuraminic acid | C00270 | HMDB00230 | 1.1E-03 | 1.0E-03 | 1.0E-03 | 9.2E-04 | 8.9E-04 | 8.1E-04 | 1.0E-03 | 4.3E-05 | 8.7E-04 | 5.6E-05 | 0.846 | 0.020 | * |
| A_0014 | Isethionic acid | C05123 | HMDB03903 | 8.2E-04 | 9.5E-04 | 1.1E-03 | 7.7E-04 | 8.8E-04 | 7.6E-04 | 9.5E-04 | 1.3E-04 | 8.0E-04 | 6.6E-05 | 0.846 | 0.172 | |
| A_0089 | UDP-glucose UDP-galactose |
C00029 C00052 |
HMDB00286 HMDB00302 |
1.2E-03 | 1.5E-03 | 1.3E-03 | 1.0E-03 | 1.1E-03 | 1.3E-03 | 1.3E-03 | 1.3E-04 | 1.1E-03 | 1.1E-04 | 0.846 | 0.110 | |
| A_0030 | N-Acetylaspartic acid | C01042 | HMDB00812 | 2.0E-01 | 2.0E-01 | 2.2E-01 | 1.8E-01 | 1.6E-01 | 1.7E-01 | 2.1E-01 | 1.0E-02 | 1.7E-01 | 8.5E-03 | 0.838 | 0.014 | * |
| A_0073 | UDP | C00015 | HMDB00295 | 1.0E-04 | 1.2E-04 | 1.2E-04 | 1.1E-04 | 8.5E-05 | 9.2E-05 | 1.2E-04 | 1.1E-05 | 9.6E-05 | 1.4E-05 | 0.833 | 0.135 | |
| A_0009 | 3-Hydroxybutyric acid | C01089, C03197 | HMDB00011, HMDB00357, HMDB00442 | 9.8E-04 | 1.2E-03 | 8.5E-04 | 7.7E-04 | 8.8E-04 | 8.4E-04 | 1.0E-03 | 1.6E-04 | 8.3E-04 | 5.6E-05 | 0.833 | 0.196 | |
| A_0054 | Sedoheptulose 7-phosphate | C05382 | HMDB01068 | 9.5E-05 | 1.1E-04 | 1.2E-04 | 6.6E-05 | 1.0E-04 | 1.1E-04 | 1.1E-04 | 1.4E-05 | 9.1E-05 | 2.2E-05 | 0.831 | 0.298 | |
| A_0042 | Pantothenic acid | C00864 | HMDB00210 | 4.1E-04 | 4.5E-04 | 4.5E-04 | 3.2E-04 | 3.7E-04 | 3.8E-04 | 4.4E-04 | 2.1E-05 | 3.6E-04 | 3.2E-05 | 0.819 | 0.029 | * |
| A_0038 | Gluconic acid | C00257 | HMDB00625 | 1.3E-04 | 1.1E-04 | 1.4E-04 | 1.1E-04 | 1.0E-04 | 9.8E-05 | 1.3E-04 | 1.3E-05 | 1.0E-04 | 6.6E-06 | 0.816 | 0.063 | |
| A_0040 | Lauric acid | C02679 | HMDB00638 | 1.5E-04 | 1.2E-04 | 1.5E-04 | 1.5E-04 | 1.1E-04 | 8.5E-05 | 1.4E-04 | 1.6E-05 | 1.1E-04 | 3.2E-05 | 0.816 | 0.308 | |
| A_0064 | AMP | C00020 | HMDB00045 | 1.6E-02 | 2.1E-02 | 2.3E-02 | 1.7E-02 | 1.3E-02 | 1.9E-02 | 2.0E-02 | 3.7E-03 | 1.6E-02 | 3.3E-03 | 0.810 | 0.248 | |
| A_0046 | Biotin | C00120 | HMDB00030 | 2.1E-04 | 2.4E-04 | 2.2E-04 | 1.7E-04 | 2.0E-04 | 1.6E-04 | 2.2E-04 | 1.7E-05 | 1.8E-04 | 1.8E-05 | 0.804 | 0.038 | * |
| A_0055 | N-Acetylglucosamine 1-phosphate | C04256 | HMDB01367 | 1.3E-04 | 1.2E-04 | 1.2E-04 | 1.2E-04 | 9.2E-05 | 9.0E-05 | 1.3E-04 | 6.0E-06 | 1.0E-04 | 1.9E-05 | 0.803 | 0.147 | |
| A_0050 | myo-Inositol 2-phosphate | – | – | 7.5E-04 | 8.0E-04 | 9.6E-04 | 5.4E-04 | 6.3E-04 | 8.3E-04 | 8.4E-04 | 1.1E-04 | 6.7E-04 | 1.5E-04 | 0.799 | 0.191 | |
| A_0045 | 2-Deoxyglucose 6-phosphate | C06369 | – | 8.4E-05 | 1.3E-04 | 6.9E-05 | 9.6E-05 | 5.2E-05 | 7.6E-05 | 9.4E-05 | 3.1E-05 | 7.4E-05 | 2.2E-05 | 0.793 | 0.434 | |
| A_0005 | Butyric acid | C00246 | HMDB00039 | 3.9E-05 | 5.5E-05 | 7.0E-05 | 4.6E-05 | 5.0E-05 | 3.4E-05 | 5.5E-05 | 1.5E-05 | 4.3E-05 | 8.2E-06 | 0.789 | 0.333 | |
| A_0059 | CMP | C00055 | HMDB00095 | 2.1E-04 | 3.5E-04 | 3.3E-04 | 2.1E-04 | 1.7E-04 | 3.0E-04 | 3.0E-04 | 7.6E-05 | 2.3E-04 | 6.8E-05 | 0.757 | 0.286 | |
| A_0076 | ADP | C00008 | HMDB01341 | 4.7E-03 | 5.7E-03 | 4.9E-03 | 3.8E-03 | 3.7E-03 | 4.0E-03 | 5.1E-03 | 5.4E-04 | 3.8E-03 | 1.3E-04 | 0.755 | 0.050 | * |
| A_0078 | Adenylosuccinic acid | C03794 | HMDB00536 | 6.4E-04 | 8.0E-04 | 7.4E-04 | 4.6E-04 | 4.7E-04 | 7.1E-04 | 7.2E-04 | 8.1E-05 | 5.4E-04 | 1.4E-04 | 0.753 | 0.153 | |
| A_0019 | Ethanolamine phosphate | C00346 | HMDB00224 | 1.3E-02 | 1.6E-02 | 1.8E-02 | 1.2E-02 | 1.1E-02 | 1.2E-02 | 1.6E-02 | 2.3E-03 | 1.2E-02 | 3.9E-04 | 0.743 | 0.091 | |
| A_0066 | GMP | C00144 | HMDB01397 | 2.5E-03 | 3.3E-03 | 3.3E-03 | 2.1E-03 | 2.0E-03 | 2.5E-03 | 3.0E-03 | 4.8E-04 | 2.2E-03 | 2.6E-04 | 0.730 | 0.079 | |
| A_0012 | Succinic acid | C00042 | HMDB00254 | 2.0E-02 | 2.1E-02 | 1.9E-02 | 1.5E-02 | 1.6E-02 | 1.3E-02 | 2.0E-02 | 1.3E-03 | 1.4E-02 | 1.7E-03 | 0.719 | 0.012 | * |
| A_0021 | 3-Phenylpropionic acid | C05629 | HMDB00764 | 1.3E-04 | 1.3E-04 | 1.1E-04 | 8.6E-05 | 8.0E-05 | 9.8E-05 | 1.2E-04 | 1.3E-05 | 8.8E-05 | 9.0E-06 | 0.715 | 0.023 | * |
| A_0095 | NAD+ | C00003 | HMDB00902 | 1.3E-03 | 1.9E-03 | 1.7E-03 | 1.2E-03 | 9.6E-04 | 1.2E-03 | 1.6E-03 | 3.2E-04 | 1.1E-03 | 1.5E-04 | 0.702 | 0.107 | |
| A_0027 | Dihydroxyacetone phosphate | C00111 | HMDB01473 | 1.9E-04 | 2.0E-04 | 2.2E-04 | 1.2E-04 | 1.7E-04 | 1.3E-04 | 2.0E-04 | 1.2E-05 | 1.4E-04 | 2.3E-05 | 0.694 | 0.024 | * |
| A_0065 | IMP | C00130 | HMDB00175 | 2.5E-03 | 2.8E-03 | 2.7E-03 | 2.1E-03 | 1.7E-03 | 1.7E-03 | 2.7E-03 | 1.7E-04 | 1.8E-03 | 2.6E-04 | 0.691 | 0.015 | * |
| A_0008 | 2-Hydroxybutyric acid | C05984 | HMDB00008 | 7.5E-05 | 8.4E-05 | 9.3E-05 | 5.1E-05 | 6.7E-05 | 5.6E-05 | 8.4E-05 | 8.9E-06 | 5.8E-05 | 8.3E-06 | 0.688 | 0.021 | * |
| A_0097 | NADP+ | C00006 | HMDB00217 | 8.3E-05 | 9.0E-05 | 8.9E-05 | 7.0E-05 | 4.4E-05 | 5.7E-05 | 8.7E-05 | 3.8E-06 | 5.7E-05 | 1.3E-05 | 0.654 | 0.045 | * |
| A_0096 | NADH | C00004 | HMDB01487 | 1.9E-04 | 2.1E-04 | 2.3E-04 | 1.5E-04 | 1.5E-04 | 1.1E-04 | 2.1E-04 | 2.3E-05 | 1.3E-04 | 2.5E-05 | 0.646 | 0.020 | * |
| A_0060 | UMP | C00105 | HMDB00288 | 5.4E-04 | 1.1E-03 | 1.1E-03 | 5.4E-04 | 4.6E-04 | 7.5E-04 | 9.1E-04 | 3.3E-04 | 5.8E-04 | 1.5E-04 | 0.641 | 0.220 | |
| A_0034 | 3-Phosphoglyceric acid | C00197 | HMDB00807 | 6.6E-04 | 5.3E-04 | 4.7E-04 | 3.3E-04 | 3.7E-04 | 3.3E-04 | 5.5E-04 | 9.5E-05 | 3.4E-04 | 2.3E-05 | 0.620 | 0.055 | |
| A_0028 | Glycerol 3-phosphate | C00093 | HMDB00126 | 4.0E-03 | 3.4E-03 | 3.9E-03 | 2.4E-03 | 3.5E-03 | 1.0E-03 | 3.8E-03 | 2.9E-04 | 2.3E-03 | 1.3E-03 | 0.612 | 0.178 | |
| A_0047 | Glucose 6-phosphate | C00668, C01172, C00092 | HMDB01401 | 8.0E-05 | 1.0E-04 | 1.2E-04 | 5.8E-05 | 5.9E-05 | 6.4E-05 | 1.0E-04 | 2.0E-05 | 6.0E-05 | 2.9E-06 | 0.598 | 0.072 | |
| A_0049 | Fructose 6-phosphate | C00085 | HMDB00124 | 2.8E-05 | 1.8E-05 | 3.4E-05 | 1.7E-05 | 1.6E-05 | 1.3E-05 | 2.7E-05 | 7.9E-06 | 1.5E-05 | 2.0E-06 | 0.574 | 0.122 | |
| A_0062 | Fructose 1,6-diphosphate | C00354 | HMDB01058 | 4.7E-04 | 4.4E-04 | 7.2E-04 | 2.7E-04 | 3.0E-04 | 2.2E-04 | 5.4E-04 | 1.5E-04 | 2.7E-04 | 4.1E-05 | 0.491 | 0.079 | |
| A_0086 | Taurocholic acid | C05122 | HMDB00036 | 1.2E-04 | 1.7E-04 | 1.6E-04 | 3.1E-05 | 1.4E-05 | ND | 1.5E-04 | 3.1E-05 | 2.3E-05 | 1.2E-05 | 0.150 | 0.010 | ** |
1Ex-GF/GF ratio.
2Welch’s t-test (*p < 0.05, **p < 0.01).
ND, not detected.