Figure 4. Efficacy of AdHu5-MVA PbMSP1₄₂ and PyMSP1₄₂ immunization.

BALB/c mice (n = 6/group) were immunized i.d. with 1 × 10¹⁰ vp AdHu5 and boosted eight weeks later i.d. with 1 × 10⁷ pfu MVA expressing (a) PyMSP1₄₂ or (b) PbMSP1₄₂. Two weeks following the final immunization vaccinated mice and non-immunized controls were challenged with (a) 1 × 10⁴ P. yoelii YM or (b,c) 5 × 10² P. berghei ANKA pRBC and monitored for parasitemia. Lines represent individual mice. † indicates that mice were culled and the number culled from the total number in the group is shown in brackets.