Table 1. Chimeric parasite challenge experiments. Protein or viral vectored vaccines were administered as shown. Regime lists dose, route and day (d) of immunizations. Survival outcome is reported for the Pb-PfM19 chimeric parasite, and wild-type Pb-PbM19 control. n.d. = not done. N/A = not applicable.
| Vaccine | Regime | Challenge | Antigen | Mouse strain | Pb-PfM19 survival | Pb-PbM19 survival |
|---|---|---|---|---|---|---|
| PfMSP119-IMX108 | 3 × 40 μg s.c. d0, d14, d28 | d42 | PfMSP119 | BALB/c | 0/6 | n.d. |
| CFA/IFA/IFA | 104 pRBC i.v. | |||||
| AdHu5-MVA | 5 × 1010 vp i.d. d0 | d70 | PfM115 | BALB/c | 0/6 | 0/6 |
| 5 × 107 pfu i.d. d56 | 104 pRBC i.v. | |||||
| Naïve | N/A | 104 pRBC i.v. | N/A | BALB/c | 0/3 + 0/6 | 0/6 |
| AdHu5-MVA | 5 × 1010 vp i.d. d0 | d70 | PfM115 | BALB/c | 0/6 | n.d. |
| 5 × 107 pfu i.d. d56 | 5 × 102 pRBC i.v. | |||||
| AdHu5-MVA | 5 × 1010 vp i.d. d0 | d70 | PfM115 | C57BL/6 | 0/6 | n.d. |
| 5 × 107 pfu i.d. d56 | 5 × 102 pRBC i.v. | |||||
| Naïve | N/A | 5 × 102 pRBC i.v. | N/A | BALB/c | 0/6 | n.d. |
| Naïve | N/A | 5 × 102 pRBC i.v. | N/A | C57BL/6 | 0/6 | n.d. |