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Dose proportionality assessment of GSK1322322 pharmacokinetic parameters
| Parameter | Adjusted mean slope value (90% CI) for GSK1322322 dose |
||
|---|---|---|---|
| 100–1,500 mg | 1,500–4,000 mg | All doses | |
| AUC0–24 (μg · h/ml) | 1.31 (1.23, 1.40) | 0.64 (0.27, 1.01) | 1.22 (1.09, 1.35) |
| AUC0–∞ (μg · h/ml) | 1.31 (1.23, 1.39) | 0.66 (0.30, 1.02) | 1.22 (1.10, 1.35) |
| AUC0–t (μg · h/ml) | 1.32 (1.24, 1.40) | 0.66 (0.30, 1.02) | 1.23 (1.10, 1.36) |
| Cmax (μg/ml) | 1.23 (1.09, 1.37) | 0.16 (−1.29, 1.62) | 1.04 (0.87, 1.22) |
