Fig 3.
Effect of AFN-1252 treatment on S. aureus in the mouse granuloma model. Subcutaneous mouse granuloma pouches were infected with 3.2 × 107 CFU of strain Wood46. (A) An oral dose of 100 mg/kg of AFN-1252 was administered at 2 h postinfection (arrow). (B) Oral doses of 100 mg/kg of AFN-1252 were administered at 2, 26, and 50 h postinfection (arrows). At the indicated times in both panels, the pouch fluid was recovered and bacterial CFU/ml of pouch fluid were determined in triplicate. CFU in pouches from animals treated with AFN-1252 (●) were compared to that in untreated controls (▲). Error bars indicate standard deviations.