Table 1.
Virulence-related genes downregulated by AFN-1252
| Locus tag | Gene | Fold changea | P value | Function |
|---|---|---|---|---|
| SA0309 | geh | 1.54 | 0.002 | Lipase |
| SA0660 | saeS | 1.77 | 0.009 | Two-component sensor |
| SA0661 | saeR | 2.45 | 0.003 | Two-component regulator |
| SA0662 | saeQ | 4.94 | 0.000 | Hypothetical |
| SA0663 | saeP | 4.40 | 0.000 | Hypothetical |
| SA1000 | ehp | 3.63 | 0.001 | Fibrinogen binding protein |
| SA1003 | efb | 3.49 | 0.000 | Fibrinogen binding protein |
| SA1007 | 1.70 | 0.009 | Alpha-toxin | |
| SA1750 | 2.05 | 0.002 | Map-w | |
| SA1752 | 8.18 | 0.000 | β-Hemolysin | |
| SA1811 | hlb | 3.63 | 0.000 | β-Hemolysin |
| SA1812 | 2.72 | 0.005 | γ-Hemolysin | |
| SA2206 | sbi | 3.72 | 0.001 | IgG binding protein |
| SA2207 | hlgA | 4.21 | 0.000 | γ-Hemolysin |
| SA2208 | hlgB | 4.99 | 0.001 | γ-Hemolysin |
| SA2209 | hlgC | 4.78 | 0.000 | γ-Hemolysin |
| SA2461 | icaD | 1.54 | 0.007 | Intracellular adhesion |
| SA2462 | icaC | 1.61 | 0.003 | Intracellular adhesion |
a
Average fold decrease in mRNA abundance derived from the Affymetrix array experiment. Triplicate control and experimental samples were analyzed. Shown are S. aureus genes with significantly (P < 0.05) different expression levels (±1.4-fold) following a 15-min treatment with 50 ng/ml AFN-1252. See Table S2 in the supplemental material for a summary of all significantly altered genes and accession number GSE19400 in the NCBI GEO database for the complete data set.