Table 3.

In vitro antimycoplasma activity against 141 clinical isolates of M. pneumoniae according to the presence or absence of a mutation in the 23S rRNA gene

Antimicrobial agent	MIC (μg/ml) for:
	MS M. pneumoniae (n = 16)			MR M. pneumoniae (n = 125)
	Range	50%	90%	Range	50%	90%
Erythromycin	0.001–0.0078	0.0039	0.0078	128–>128	>128	>128
Clarithromycin	0.001–0.0156	0.002	0.0039	128–>128	>128	>128
Azithromycin	0.000125–0.001	0.00025	0.0005	16–>128	64	128
Minocycline	0.25–2	1	2	0.25–4	1	2
Tosufloxacin	0.125–0.5	0.25	0.5	0.125–0.5	0.25	0.5