Table 2.
In vitro activities of GSK225105 and comparator antimicrobial agents against 916 strains of anaerobic bacteriaa
| Organism (nb) | Drug | MIC (μg/ml) |
% I or R | ||
|---|---|---|---|---|---|
| Range | 50% | 90% | |||
| Bacteroides fragilis (200) | GSK225105 | 1–8 | 2 | 4 | |
| Moxifloxacin | 0.125–>32 | 1 | 16 | 30.5 | |
| Metronidazole | 0.06–>32 | 1 | 4 | 1 | |
| Imipenem | 0.03–>32 | 0.125 | 1 | 2.5 | |
| Piperacillin-tazobactam | ≤0.015–>128 | 0.25 | 2 | 1.5 | |
| Bacteroides thetaiotaomicron (102) | GSK225105 | 2–16 | 4 | 8 | |
| Moxifloxacin | 1–>32 | 2 | 32 | 24.5 | |
| Metronidazole | 0.125–4 | 1 | 2 | 0 | |
| Imipenem | 0.06–2 | 0.25 | 1 | 0 | |
| Piperacillin-tazobactam | 0.25–>128 | 4 | 16 | 1 | |
| Bacteroides fragilis group, other (63)c | GSK225105 | 1–16 | 4 | 8 | |
| Moxifloxacin | 0.25–>32 | 4 | 32 | 39.7 | |
| Metronidazole | 0.125–4 | 1 | 1 | 0 | |
| Imipenem | 0.06–2 | 0.25 | 1 | 0 | |
| Piperacillin-tazobactam | ≤0.015–16 | 2 | 8 | 0 | |
| Bilophila wadsworthia (54) | GSK225105 | 0.5–2 | 1 | 1 | |
| Moxifloxacin | ≤0.06–4 | 0.25 | 1 | 0 | |
| Metronidazole | ≤0.06–0.25 | 0.125 | 0.25 | 0 | |
| Imipenem | 0.125–>32 | 0.25 | >32 | 33.3 | |
| Piperacillin-tazobactam | 16–>128 | 32 | >128 | 42.6 | |
| Fusobacterium spp. (50)d | GSK225105 | 0.25–4 | 0.5 | 2 | |
| Moxifloxacin | 0.125–16 | 0.25 | 0.5 | 10 | |
| Metronidazole | ≤0.03–2 | 0.125 | 0.5 | 0 | |
| Imipenem | ≤0.015–0.25 | 0.06 | 0.25 | 0 | |
| Piperacillin-tazobactam | ≤0.015–0.125 | 0.03 | 0.06 | 0 | |
| Prevotella spp. (50)e | GSK225105 | 0.5–16 | 2 | 4 | |
| Moxifloxacin | 0.125–64 | 2 | 0.5 | 20 | |
| Metronidazole | 0.06–4 | 1 | 2 | 0 | |
| Imipenem | ≤0.015–0.25 | 0.06 | 0.125 | 0 | |
| Piperacillin-tazobactam | ≤0.015–1 | ≤0.015 | 0.06 | 0 | |
| Porphyromonas spp. (51)f | GSK225105 | 0.125–2 | 0.5 | 1 | |
| Moxifloxacin | ≤0.03–16 | 0.5 | 1 | 2 | |
| Metronidazole | ≤0.03–1 | 0.125 | 0.5 | 0 | |
| Imipenem | ≤0.015–0.125 | 0.03 | 0.06 | 0 | |
| Piperacillin-tazobactam | ≤0.015–0.03 | ≤0.015 | ≤0.015 | 0 | |
| C. difficile (102) | GSK225105 | 2–8 | 4 | 4 | |
| Moxifloxacin | 0.5–>32 | 1 | 16 | 30.4 | |
| Metronidazole | 0.25–2 | 0.5 | 1 | 0 | |
| Imipenem | 2–16 | 8 | 16 | 10.8 | |
| Piperacillin-tazobactam | 4–64 | 8 | 16 | 1 | |
| Clostridium spp. (52)g | GSK225105 | 1–>32 | 4 | >32 | |
| Moxifloxacin | 0.25–32 | 1 | 8 | 25 | |
| Metronidazole | ≤0.03–2 | 0.25 | 2 | 0 | |
| Imipenem | 0.03–2 | 0.25 | 2 | 0 | |
| Piperacillin-tazobactam | ≤0.015–16 | 0.25 | 4 | 0 | |
| Eggerthella lenta (27) | GSK225105 | 0.25–1 | 0.5 | 1 | |
| Moxifloxacin | 0.25–>32 | 0.5 | 32 | 29.6 | |
| Metronidazole | 0.25–0.5 | 0.5 | 0.5 | 0 | |
| Imipenem | 0.25–0.5 | 0.25 | 0.25 | 0 | |
| Piperacillin-tazobactam | 8–32 | 16 | 32 | 0 | |
| Eubacterium group (60)h | GSK225105 | 0.25–4 | 1 | 2 | |
| Moxifloxacin | 0.06–8 | 0.5 | 1 | 1.8 | |
| Metronidazole | 0.125–4 | 0.5 | 2 | 0 | |
| Imipenem | ≤0.015–0.5 | 0.06 | 0.25 | 0 | |
| Piperacillin-tazobactam | ≤0.015–1 | 0.25 | 1 | 0 | |
| Anaerobic Gram-positive cocci (51)i | GSK225105 | 0.5–32 | 4 | 8 | |
| Moxifloxacin | ≤0.06–16 | 0.5 | 2 | 5.9 | |
| Metronidazole | 0.25–2 | 0.5 | 2 | 0 | |
| Imipenem | ≤0.015–0.25 | 0.06 | 0.125 | 0 | |
| Piperacillin-tazobactam | ≤0.015–0.25 | 0.03 | 0.125 | 0 | |
| Bifidobacterium spp. (27)j | GSK225105 | 0.25–0.5 | 0.25 | 0.5 | |
| Moxifloxacin | 0.06–16 | 1 | 8 | 37 | |
| Metronidazole | 0.5–>32 | 16 | >32 | 37 | |
| Imipenem | ≤0.015–2 | 0.06 | 0.5 | 0 | |
| Piperacillin-tazobactam | ≤0.015–2 | 0.06 | 1 | 0 | |
| Lactobacillus spp. (27)k | GSK225105 | 0.5–8 | 4 | 8 | |
| Moxifloxacin | 0.25–16 | 0.5 | 8 | 11.1 | |
| Metronidazole | 2–>32 | >32 | >32 | 96.3 | |
| Imipenem | 0.03–16 | 0.5 | 4 | 3.7 | |
| Piperacillin-tazobactam | ≤0.015–4 | 1 | 4 | 0 | |
B. fragilis and B. thetaiotaomicron were tested by the broth microdilution method; the remaining anaerobes were tested by agar dilution. I, intermediate; R, resistant.
n, no. of isolates.
Bacteroides caccae (8 isolates), Bacteroides ovatus (12 isolates), Bacteroides uniformis (13 isolates), Bacteroides vulgatus (13 isolates), Parabacteroides distasonis (11 isolates), Parabacteroides goldsteinii (4 isolates), and Parabacteroides merdae (2 isolates).
Fusobacterium necrophorum (10 isolates) and F. nucleatum (40 isolates).
Prevotella bergensis (2 isolates), P. bivia (15 isolates), P. buccae (9 isolates), P. denticola (2 isolates), P. heparinolytica (1 isolate), P. intermedia, (1 isolate), P. loescheii (2 isolates), P. melaninogenica (7 isolates), P. nanciensis (4 isolates), P. oralis (1 isolate), P. oris (1 isolate), and P. timonensis (4 isolates).
Porphyromonas asaccharolytica (20 isolates), P. endodontalis (2 isolates), P. gingivalis (4 isolates), P. gulae (1 isolate), P. levii (1 isolate), P. somerae (17 isolates), and P. uenonis (4 isolates).
Clostridium aminovalericum (1 isolate), C. butyricum (3 isolates), C. cadaveris (2 isolates), C. celerecrescens (2 isolates), C. clostridioforme (7 isolates), C. hathewayi (2 isolates), C. innocuum (10 isolates), C. paraputrificum (2 isolates), C. perfringens (11 isolates), C. ramosum (7 isolates), C. scindens (1 isolate), C. sordelii (1 isolate), C. symbiosum (2 isolates), and C. tertium (1 isolate).
Atopobium parvulum (4 isolates), Atopobium rimae (6 isolates), Collinsella aerofaciens (4 isolates), Eubacterium cylindroides (1 isolate), Eubacterium limosum (13 isolates), Mogibacterium neglectum (1 isolate), Mogibacterium timidum (3 isolates), Olsenella uli (4 isolates), Pseudoramibacter alactolyticus (9 isolates), Slackia exigua (9 isolates), and Solobacterium moorei (6 isolates).
Anaerococcus vaginalis (2 isolates), Finegoldia magna (17 isolates), Parvimonas micra (16 isolates), Peptoniphilus harei (5 isolates), Peptoniphilus asaccharolyticus (7 isolates), and Peptostreptococcus anaerobius (3 isolates).
Bifidobacterium adolescentis (6 isolates), B. angulatum (1 isolate), B. animalis (1 isolate), B. bifidum (3 isolates), B. breve (4 isolates), B. catenulatum (1 isolate), B. dentium (2 isolates), B. longum (7 isolates), B. pseudocatenulatum (1 isolate), and B. ruminatum (1 isolate).
Lactobacillus casei (4 isolates), L. catenaformis (1 isolate), L. crispatus (3 isolates), L. fermentans (3 isolates), L. gasseri/L. johnsonii (5 isolates), L. oris (1 isolate), L. rhamnosus (9 isolates), and L. vaginalis (1 isolate).