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Observed and model-simulated plasma azithromycin concentration-versus-time profiles following administration of single 10- and 20-mg/kg doses of azithromycin given i.v. to preterm neonates relative to in vitro MIC90 (4 μg/ml) and MIC50 (1 μg/ml). Data for the 10-mg/kg dose were previously published (13).
