Table 1.
Comparison of characteristics of the 20-mg/kg azithromycin single-dose combined cohort and stratified by Ureaplasma respiratory tract colonization status
| Variablea | No. of subjects (%) or parameter value (mean ± SD) for: |
P valueb | ||
|---|---|---|---|---|
| All subjects (n = 13) | Ureaplasma-positive subjects (n = 7) | Ureaplasma-negative subjects (n = 6) | ||
| Gestational age (wk) | 25.6 ± 1.2 | 25.6 ± 1.3 | 25.7 ± 1.2 | 0.893 |
| Birth weight (g) | 870 ± 116 | 914 ± 129 | 818 ± 80 | 0.143 |
| Sex (male) | 10 (77) | 4 (57) | 6 (100) | 0.067 |
| Race | ||||
| White | 6 (46) | 3 (43) | 3 (50) | |
| African-American | 6 (46) | 4 (57) | 2 (33) | 0.450 |
| Asian | 1 (8) | 0 | 1 (17) | |
| Mixed | 0 | 0 | 0 | |
| Ethnicity (Hispanic) | 0 | 0 | 0 (0) | 1.0 |
| Positive-pressure support at study entry | ||||
| CPAP | 4 (31) | 3 (43) | 1 (17) | 0.308 |
| IMV/HFOV | 9 (69) | 4 (57) | 5 (83) | |
| IMV duration at study entry | 27.7 ± 15.8 | 36.1 ± 16.2 | 17.8 ± 8.2 | 0.030 |
| FiO2 at study entry | 0.24 ± 0.01 | 0.22 ± 0.02 | 0.26 ± 0.04 | 0.073 |
| Postnatal age at dose (h) | 64.9 ± 30.3 | 60.2 ± 26.0 | 70.3 ± 36.5 | 0.573 |
a
CPAP, continuous positive airway pressure; IMV, intermittent mandatory ventilation; HFOV, high-frequency oscillatory ventilation; FiO2, delivered fraction of inspired oxygen concentration.
b
Statistical comparison between ureaplasma-positive subjects and ureaplasma-negative subjects.