Table 2.
Parameter estimates of the population modela
| Parameterb | Estimate (% RSE) | % ISV (% RSE) |
|---|---|---|
| CL (liter/h) | 0.21 × WT(kg)0.75 (6) | 31 (27) |
| V1 (liter) | 1.97 × WT(kg) (19) | 86 (39) |
| Q (liter/h) | 2.1 × WT(kg)0.75 (9) | 39 (39) |
| V2 (liter) | 17.9 × WT(kg) (9) | 39 (31) |
| Residual error (%) | 24.5 (29) |
a
ISV, intersubject variability, calculated as the square root of the estimated variance of intersubject variability × 100; RSE, relative standard error; WT(kg), body weight (in kilograms); WT(kg)0.75, body weight (in kilograms) allometrically scaled with a fixed exponent of 0.75.
b
CL, clearance; V1, volume of distribution in the central compartment; Q, blood flow; V2, volume of distribution in the peripheral compartment.