Table 3.
Rates of selection of resistance and high-level resistance after exposure to daptomycin
| Microorganism(s) | No. of strains | No. (%) screening positivea | No. (%) that wereb: |
|
|---|---|---|---|---|
| DNS (MIC, ≥2 mg/liter) | HLDR (MIC, ≥256 mg/liter) | |||
| Mitis group | 92 | 74 (80) | 61 (66) | 25 (27) |
| S. mitis | 51 | 35 (69) | 30 (59) | 14 (27) |
| S. oralis | 19 | 18 (95) | 14 (74) | 9 (47) |
| S. sanguis | 15 | 15 (100) | 11 (73) | 2 (13) |
| S. gordonii | 4 | 4 (100) | 4 (100) | 0 (0) |
| S. parasanguis | 3 | 2 (67) | 2 (67) | 0 (0) |
| Bovis group | 54 | 2 (4) | 0 | 0 |
| Anginosus group | 10 | 5 (50) | 5 (50) | 0 |
| Mutans group | 8 | 0 | 0 | 0 |
| Salivarius group | 4 | 0 | 0 | 0 |
a
Screening was considered positive if the microorganism grew in the presence of 0.5 mg or 1 mg/liter daptomycin.
b
DNS, daptomycin nonsusceptible; HLDR, high-level daptomycin resistance.