Table 4.

Rates of high-level daptomycin resistance according to baseline MIC or MBC of isolates from the mitis group

Test, parameter	No. of isolates with result/total no. of isolates (%)		P value
	HLDR	Not HLDR
Microdilution, MIC50 = 0.5 (mg/liter)
MIC ≤ 0.5	9/55 (16)	46/55 (84)	0.004
MIC > 0.5	17/37 (46)	20/37 (54)
Etest, MIC50 = 0.25 (mg/liter)
MIC ≤ 0.25	11/55 (20)	44/55 (80)	0.056
MIC > 0.25	15/37 (40)	22/37 (60)
Microdilution, MBC50 = 2 (mg/liter)
MBC ≤ 2	9/56 (16)	47/56 (84)	0.006
MBC > 2	16/36 (44)	20/36 (56)
Microdilution, MBC/MIC ≥ 8 (mg/liter)
MBC/MIC ≤ 4	12/57 (21)	45/57 (79)	0.085
MBC/MIC ≥ 8	14/35 (40)	21/35 (60)