Table 5.

Treatment of experimental endocarditis caused by S. mitis 351 strain

Treatment group	No. of sterile vegetations/total no. of vegetations (%)	Log10 CFU/g vegetation [median (IQR)]	No. of recovered isolates with HLDR MIC/total no. of animals treated (%)l
Controla	0/15 (0)	9.1 (9–9.6)	0
RD-daptomycin	1/11 (9)b	6.7 (5.9–7.8)c	7/11 (63)d
HD-daptomycin	1/12 (8)e	6.1 (5.2–7.2)f,g	8/12 (67)h
Vancomycin	0/12 (0)i	3.4 (2–4)g,j	NA
RD-daptomycin + gentamicin	10/11 (91)b,k	0 (0–0)c	1/11 (9)d
HD-daptomycin + gentamicin	8/12 (67)e	0 (0–2)f	1/12 (8)h
Vancomycin + gentamicin	6/12 (50)i,k	1 (0–2.2)j	NA

^aThe control animals were sacrificed 24 h after the infection was started.

^bP < 0.001.

^cP < 0.001.

^dP = 0.004.

^eP = 0.003.

^fP = 0.002.

^gP = 0.001.

^hP = 0.004.

ⁱP = 0.005.

^jP = 0.002.

^kP = 0.03.

^lNA, not applicable.