Table 10.
Number of clones for specimens from patient N (GT-1a infected), treated QD with 60 mg of DCV
| Mutation(s) | No. of clones at the indicated time point |
|||||
|---|---|---|---|---|---|---|
| T0 | D14-1a | D14-2a | D15 | D21 | D182 | |
| None (WT) | 46 | 4 | 7 | 6 | 1 | |
| M28G | 2 | 5 | 2 | |||
| M28V | 4 | |||||
| Q30E | 36 | 26 | 57 | 51 | 59 | |
| Q30G | 1 | |||||
| Q30H | 4 | 6 | 2 | |||
| Q30R | 1 | 1 | ||||
| L31R | 1 | |||||
| L31V | 1 | |||||
| Y93N | 21 | 29 | 29 | 17 | ||
| M28A-Q30R | 14 | 2 | ||||
| M28T-Q30H | 27 | 16 | 11 | |||
| M28T-Q30K | 27 | |||||
| M28T-Q30R | 1 | 16 | 3 | 11 | 33 | |
| M28T-L31M | 6 | 6 | 8 | |||
| M28V-Q30E | 1 | |||||
| M28V-Y93N | 1 | 1 | ||||
| Q30E-Y93C | 1 | |||||
| Q30E-Y93N | 4 | 1 | 2 | |||
| Q30E-Y93T | 1 | |||||
| Q30H-Y93H | 1 | |||||
| Q30R-L31M | 4 | 9 | 9 | |||
| L31P-Y93N | 1 | |||||
| H58R-Y93N | 1 | |||||
| H58T-Y93T | 1 | 1 | ||||
| M28A-Q30R-Y93N | 3 | |||||
| M28T-Q30H-Y93N | 3 | 1 | ||||
| M28T-Q30H-Y93T | 1 | |||||
| M28T-Q30R-Y93N | 3 | |||||
| M28T-L31M-Y93N | 1 | 1 | ||||
| Q30E-H58P-Y93L | 1 | |||||
| Q30E-H58T-Y93T | 1 | 1 | ||||
| Q30R-L31M-Y93N | 1 | 1 | ||||
| M28T-Q30H-H58P-Y93L | 1 | |||||
| M28T-L31M-H58T-Y93T | 1 | |||||
| M28T-Q30R-L31T-H58P-Y93L | 1 | |||||
| Total clones | 51 | 64 | 93 | 150 | 151 | 151 |
a
Two different primer sets (-1 and -2) were used for the same specimen derived from day 14.