Table 11.
Variant persistence in HCV patients after treatment QD with 100 mg of DCV by population sequence
| Patient | Genotype | Time | RNA (IU/ml) | Substitution(s) (% frequency)a |
Additional mutation (% frequency) | |||
|---|---|---|---|---|---|---|---|---|
| M/L28 | Q/R30 | L31 | Y93 | |||||
| Q | 1a | T0 | 1.1E+06 | WT | WT | WT | WT | |
| Day 14 | 3.6E+02 | T (∼50%) | E (∼50%), H (∼20%) | C (∼35%) | ||||
| Day 15 | 3.4E+02 | Failed to generate PCR products | Failed to generate PCR products | Failed to generate PCR products | Failed to generate PCR products | |||
| Day 21b | 8.0E+02 | T (∼75%) | D (∼20%), H (∼80%) | |||||
| Day 28 | 3.5E+03 | E (∼50%) | N (∼50%) | |||||
| Day 42 | 4.1E+04 | T (∼25%) | D (∼10%), E (∼45%), H (∼10%) | C (∼10%) | ||||
| Day 98 | 4.4E+05 | T (∼20%) | D (∼7.5%). E (∼55%), H (∼5%) | |||||
| Day 182 | 5.1E+05 | T (∼5%) | E (∼80%) | |||||
| R | 1a | T0 | 3.5E+05 | WT | WT | WT | WT | |
| T12 | 1.4E+03 | H (∼60%) | H (∼25%) | |||||
| Day 14 | 4.2E+04 | T (∼50%) | E (∼10%), H (∼37.5%) | |||||
| Day 15 | 1.2E+05 | T (∼60%) | E (∼17.5%), H (∼50%), R (∼10%) | |||||
| Day 21 | 3.7E+05 | T (∼67.5%) | E (∼17.5%), H (∼70%), R (∼12.5%) | |||||
| Day 28 | 1.9E+05 | T (∼75%) | E (∼20%), H (∼65%), R (∼15%) | |||||
| Day 42 | 9.4E+04 | T (∼82.5%) | E (∼7.5%), H (∼82.5%), R (∼10%) | |||||
| Day 98 | 4.1E+05 | T (∼100%) | H (∼95%) | |||||
| Day 182 | 6.1E+05 | E (∼100%) | ||||||
| S | 1a | T0 | 1.0E+07 | WT | WT | WT | WT | |
| Day 14 | 2.4E+07 | R (∼100%) | H58D (∼100%) | |||||
| Day 15 | 7.6E+06 | T (<5%) | R (∼92.5%) | M (∼5%) | H58D (∼92.5%) | |||
| Day 21 | 1.3E+07 | T (<5%) | H (∼5%), R (∼85%) | M (∼5%) | H58D (∼85%) | |||
| Day 28 | 1.8E+07 | T (<5%) | H (∼2.5%), R (∼85%) | M (∼5%) | H58D (∼85%) | |||
| Day 42 | 1.1E+07 | T (∼5%) | R (∼92.5%) | M (<5%) | H58D (∼92.5%) | |||
| Day 92 | 2.0E+07 | R (∼95%) | M (∼5%) | H58D (∼95%) | ||||
| Day 177 | 1.5E+07 | T (∼2.5%) | R (∼95%) | M (∼5%) | H58D (∼92.5%) | |||
| T | 1b | T0 | 2.0E+07 | H (∼100%) | Q54H (∼100%) | |||
| Day 14 | 8.4E+05 | V (∼100%) | H (∼100%) | Q54H (∼100%) | ||||
| Day 15 | 4.6E+06 | V (∼100%) | H (∼100%) | Q54H (∼100%) | ||||
| Day 21 | 5.7E+06 | V (∼100%) | H (∼100%) | Q54H (∼100%) | ||||
| Day 28 | 1.1E+07 | V (∼100%) | H (∼100%) | Q54H (∼100%) | ||||
| Day 45 | 1.1E+07 | V (∼100%) | H (∼100%) | Q54H (∼100%) | ||||
| Day 98 | 2.0E+07 | V (∼100%) | H (∼100%) | Q54H (∼100%) | ||||
| Day 182 | 1.4E+07 | V (∼100%) | H (∼100%) | Q54H (∼100%) | ||||