Table 1.
Strain | Date of isolation (day/mo/yr) | Patient age | Sex | Source | IMP MIC (μg/ml) | Resistance phenotype |
VIM-2 production | Sequence type | |||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
TIC | TCC | TZP | CAZ | GEN | CIP | FOS | COL | ||||||||
1 | 15/12/2010 | 42 yr | M | Bronchial aspirate | 12 | R | R | R | R | R | S | S | S | + | ST1420 |
2 | 15/12/2010 | 18 yr | F | Blood | 32 | R | R | R | R | R | S | S | S | + | ST1420 |
3 | 28/12/2010 | 18 mo | M | Bronchial aspirate | 12 | R | R | R | R | R | S | S | S | + | ST162 |
4 | 25/02/2011 | 2 mo | M | Bronchial aspirate | 8 | R | R | R | R | R | R | R | S | + | ST1420 |
5 | 27/02/2011 | 7 yr | M | Bronchial aspirate | 16 | R | R | R | R | R | R | R | S | + | ST1420 |
6 | 08/03/2011 | 7 days | M | Bronchial aspirate | 32 | R | R | R | R | S | S | R | S | + | ST1420 |
7 | 22/03/2011 | 57 yr | M | Urinary catheter | 12 | R | R | R | R | R | R | S | S | + | ST1420 |
8 | 23/03/2011 | 43 yr | M | Urinary catheter | 32 | R | R | R | R | S | S | R | S | + | ST1420 |
9 | 18/04/2011 | 35 yr | M | Urine | 12 | R | R | R | R | S | S | R | S | + | ST1420 |
10 | 25/05/2011 | 7 yr | M | Pus | 16 | R | R | R | R | R | S | R | S | + | ST1420 |
11 | 19/06/2011 | 46 yr | M | Urine | 16 | R | R | R | R | S | R | S | S | + | ST1420 |
12b | 22/06/2011 | 58 yr | F | Bronchial aspirate | 32 | R | R | R | R | R | S | S | S | − | ST1175 |
13c | 22/07/2011 | 40 yr | M | Bronchial aspirate | 32 | R | R | R | R | S | S | R | S | − | ST1420 |
14 | 18/08/2011 | 54 yr | M | Wound | 16 | R | R | R | R | R | S | S | S | + | ST1420 |
15 | 27/08/2011 | 5 yr | M | Wound | 12 | R | R | R | R | S | S | R | S | + | ST1420 |
16d | 10/09/2011 | 10 yr | M | Urine | 16 | R | R | R | R | R | R | R | S | − | ST654 |
17 | 27/08/2011 | 45 yr | M | Wound | 12 | R | R | R | R | R | S | S | S | + | ST1420 |
CAZ, ceftazidime; CIP, ciprofloxacin; COL, colistin; FOS, fosfomycin; GEN, gentamicin; TCC, ticarcillin-clavulanic acid; TIC, ticarcillin; TZP, piperacillin-tazobactam; M, male; F, female; R, resistant; S, susceptible. MICs were determined by the Etest.
Contains a 529CGA-to-TGA mutation, leading to a stop codon in the oprD gene.
Exhibits a 193TGGA-to-TG·A deletion, leading to a stop codon in the oprD gene.
Contains a 757TCG-to-TAG mutation, leading to a stop codon in the oprD gene.