Table 2.
Area under the bacterial killing curve (AUBC) of 2- or 3-drug combinations against 12 KPC K. pneumoniae isolates
| Drug(s) | Median AUBC (log10 CFU/ml · h) (interquartile range)a |
P value |
|
|---|---|---|---|
| Vs colistinb | Vs colistin-doripenemc | ||
| Colistin | 123.9 (114.1–128.1) | NA | 0.0005 |
| Colistin-ertapenem | 112.8 (98.3–120.9) | 0.03 | 0.07 |
| Colistin-doripenem | 93.0 (84.1–107.5) | 0.0005 | NA |
| Colistin-doripenem-ertapenem | 82.8 (73.0–91.8) | <0.0001 | 0.05 |
a
Calculated using GraphPad Prism 6 software. A more effective drug regimen yields a lower AUBC.
b
The AUBCs of colistin-ertapenem, colistin-doripenem, and colistin-doripenem-ertapenem were significantly lower than the AUBC of colistin alone.
c
The AUBC of colistin-doripenem-ertapenem was significantly lower than the AUBC of colistin-doripenem. NA, not applicable.