Table 1.
MIC and FICI values for the combinations of farnesol with the antifungal agents caspofungin, voriconazole, and itraconazole against strains of C. posadasiia
| MIC range (mg/liter) of indicated drug alone |
MIC range (mg/liter) of indicated drug in combination |
FICI (range) | No. (%) of strains showing synergistic effects | ||||
|---|---|---|---|---|---|---|---|
| FNZ | Antifungal | FNZ | Antifungal | ||||
| 0.00171–0.01369 | ITR | 0.125–0.5 | 0.000107–0.003424 | ITR | 0.0078–0.0312 | 0.125–1 | 12 (66.6) |
| VRZ | 0.125–0.25 | 0.000428–0.001712 | VRZ | 0.0156–0.125 | 0.125–2 | 15 (83.3) | |
| CAS | 32–16 | 0.000107–0.003424 | CAS | 1–8 | 0.125–1 | 17 (94.4) | |
| AMB | 0.0625–0.125 | 0.000428–0.003424 | AMB | 0.0078–0.0312 | 0.25–1 | 17 (94.4) | |
a
FNZ, farnesol; AMB, amphotericin B; ITR, itraconazole; VRZ, voriconazole; CAS, caspofungin.