Table 2.
Pharmacokinetic parameters of OP and OC in mallard ducks administered a single oral dose (5 mg) of OP
| Parameter (units) | Valuea |
|
|---|---|---|
| OP | OC | |
| Cmax (ng/ml) | 1,190 (575) | 487 (188) |
| Tmax (h) | 0.54 (0.71) | 0.46 (0.10) |
| AUC0–12 (ng · h/ml) | 5,490 (2,500) | 1,140 (382) |
| AUC0–t (ng · h/ml) | 10,500 (4,030) | 1,240 (528) |
| AUC0–∞ (ng · h/ml) | 11,000 (4,240) | 1,390 (548) |
| AUC0–∞ (ng · h/ml/mg) | 2,200 (847) | 303 (119) |
| t1/2 (h) | 10.5 (3.00) | 6.48 (1.61) |
| CL/F (liters/h) | 0.517 (0.206) | NC |
| CL/F (liters/h/kg) | 0.468 (0.191) | NC |
| Vz/F (liters) | 7.67 (3.60) | NC |
| Vz/F (liters/kg) | 6.81 (2.91) | NC |
a
Values are means (standard deviations) from 6 experiments. NC, not calculated.