Table 3.
Comparison of pharmacokinetic parameters of OP and OC in mallard ducks and humans following a single oral dose of OP
| Parameter (unit) | Valuea |
|||
|---|---|---|---|---|
| Oseltamivir |
Oseltamivir carboxylate |
|||
| Duck | Human | Duck | Human | |
| Cmax (ng/ml) | 1,190 | 84 | 487 | 215 |
| Tmax (h) | 0.54 | 1.00 | 0.46 | 5.00 |
| AUC0–∞ (ng · h/ml/mg) | 2,200 | 1.87 | 303 | 40.8 |
| t1/2 (h) | 10.5 | 1.70 | 6.48 | 7.7 |
| CL/F (liters/h/kg) | 0.47 | 7.1 | NC | NC |
| Vz/F (liters/kg) | 6.81 | 17.6 | NC | NC |
a
Pharmacokinetic parameters for ducks following a single oral dose of 5 mg of OP (current study); mean duck weight = 1.11 kg. Pharmacokinetic parameters for humans given a 75-mg oral dose of OP (clinical study WP20727 [57]); mean human weight = 75 kg. NC, not calculated.