Table 5.
IC50 comparisons between control sensitive and resistant strains
| Virus strain | NA subtype | NA mutation | Mean IC50 ± SDa (nM) (fold inc) |
|---|---|---|---|
| A/TX/36/1991 | N1 | 3.20 ± 1.01 | |
| A/TX/36/1991 | N1 | H274Y | 262.3 ± 204.4 (81.96) |
| A/Wuhan/395/1995-like | N2 | 3.215 ± 0.73 | |
| A/Wuhan/395/1995-like | N2 | E119V | 26.25 ± 4.25 (8.16) |
| A/Mallard/182742/1998 | N2 | 1.97 ± 1.16 | |
| A/Mallard/182742/1998 | N2 | E119V | 17.43 ± 4.85 (8.84) |
| A/Mallard/346250/2000 | N2 | 5.14 ± 1.23 |
a
Means ± SD calculated from data collected from at least 3 independent experiments. fold inc, fold increase in IC50 for oseltamivir compared to that of the matching wild-type strain.