Table 8.

Biclusters containing the miR-17-92 gene cluster family

ID	miRNAs	mRNAs	miRNA GC	pMF	pBP	q
Hierarchy level 2
6	mir-17, mir-20a	APP, BCL2, BMPR2, CCND1, CCND2, CDKN1A, E2F1, E2F3, MAP3K12, MAPK9, MEF2D, MYC, PTEN, RB1, RBL1, RBL2, RUNX1, SMAD4, TGFBR2, THBS1, VEGFA, WEE1	miR-17-92	3.96 E-6	3.37 E-7	1.0
22	mir-93, mir-106b	CDKN1A, E2F1, KAT2B, MAPK9, VEGFA	miR-106b-25	1.00	1.30 E-6	1.0
31	mir-20b, mir-106a	ARID4B, CDKN1A, HIPK3, MYLIP, VEGFA	miR-106a-363	1.00	1.00	1.0
58	mir-17, mir-21, mir-18a, mir-19b	NCOA3, PTEN	miR-17-92	1.00	1.00	1.0
66	mir-17, mir-19a, mir-20a, mir-92a	BMPR2, SMAD4, TGFBR2	miR-17-92	5.53 E-41	3.23 E-31	1.0
67	mir-19b, mir-20b, mir-92a, mir-106a	ARID4B, HIPK3, MYLIP	miR-17-92, miR106a-363	1.00	0.03	1.0
70	mir-17, mir-20a, mir-106a	CDKN1A, E2F1, RB1, RUNX1, VEGFA	miR-17-92, miR106a-363	5.77 E-4	1.99 E-9	1.0
72	mir-17, mir-20a, mir-106b	APP, CCND2, E2F3, MAPK9, RBL1, RBL2, WEE1	miR-17-92, miR-106b-25	1.00	5.00 E-24	1.0
Hierarchy level 2
6-72	mir-17, mir-20a, mir-106b	APP, BCL2, BMPR2, CCND1, CCND2, CDKN1A, E2F1, E2F3, MAP3K12, MAPK9, MEF2D, MYC, PTEN, RB1, RBL1, RBL2, RUNX1, SMAD4, TGFBR2, THBS1, VEGFA, WEE1	miR-17-92, miR106b-25	1.90 E-5	6.46 E-5	0.8
22-70	mir-17, mir-93, mir-20a, mir-106a, mir-106b	CDKN1A, E2F1, KAT2B, MAPK9, RB1, RUNX1, VEGFA	miR-17-92, miR-106b-25, miR106a-363	1.60 E-5	1.07 E-7	0.8
58-66	mir-17, mir-21, mir-18a, mir-19a, mir-19b, mir-20a, mir-92a	BMPR2, NCOA3, PTEN, SMAD4, TGFBR2	miR-17-92	3.18 E-9	1.30 E-8	0.8
Hierarchy level 3
6-72-22-70	mir-17, mir-93, mir-20a, mir-106a, mir-106b	APP, BCL2, BMPR2, CCND1, CCND2, CDKN1A, E2F1, E2F3, KAT2B, MAP3K12, MAPK9, MEF2D, MYC, PTEN, RB1, RBL1, RBL2, RUNX1, SMAD4, TGFBR2, THBS1, VEGFA, WEE1	miR-17-92, miR-106b-25, miR106a-363	2.46 E-4	1.56 E-4	0.6

Biclusters containing the miR-17-92 gene cluster family, extracted from miRTarBase_filt with α = 0.2. The column miRNA GC contains the corresponding gene cluster in the miR-17-92 family.