Table 9.
Biclusters containing co-targeting on KAT2B
| ID | pMF | pBP | q | miRNAs | mRNAs | mRNA Function | Reactome Mapping (p-value) |
|---|---|---|---|---|---|---|---|
| Hierarchy level 1 | |||||||
| 41 | 0.40 | 0.05 | 1.00 | miR-181a, miR-181b | NLK | Serine/threonine-protein kinase that regulates a number of transcription factors with key roles in cell fate determination. Positive effector of the non-canonical Wnt signaling pathway and negative regulator of the canonical Wnt/beta-catenin signaling pathway and of Notch signaling pathway | none |
| BCL2* | Integral outer mitochondrial membrane protein that regulate and contribute to programmed cell death or apoptosis | none | |||||
| CDX2 | Transcription factor. Important in broad range of functions from early differentiation to maintenance of the intestinal epithelial lining of both the small and large intestine | none | |||||
| GATA6 | Member of a small family of zinc finger transcription factors that play an important role in the regulation of cellular differentiation and organogenesis during vertebrate development | none | |||||
| KAT2B* | Functions as a histone acetyltransferase (HAT) to promote transcriptional activation. Inhibits cell-cycle progression | none | |||||
| PLAG1 | Transcription factor whose activation results in up-regulation of target genes, such as IGFII, leading to uncontrolled cell proliferation: when overexpressed in cultured cells, higher proliferation rate and transformation are observed | none | |||||
| 65 | 1.00 | 1.00 | 1.00 | miR-25, miR-32,miR-19a | KAT2B* | Functions as a histone acetyltransferase (HAT) to promote transcriptional activation. Inhibits cell-cycle progression | none |
| PRMT5 | Protein arginine methyltransferase 5. Plays a role in the assembly of snRNP core particles. May play a role in cytokine-activated transduction pathways. Negatively regulates cyclin E1 promoter activity and cellular proliferation | none | |||||
| BCL2L11 | Integral outer mitochondrial membrane protein that regulate and contribute to programmed cell death or apoptosis. | none | |||||
| Hierarchy level 2 | |||||||
| 16-65 | 1.00 | 0.07 | 0.639 | miR-25, miR-32, miR-19a, miR-19b | ESR1† | Estrogen receptor. Ligand-activated transcription factor composed of several domains important for hormone binding, DNA binding, and activation of transcription. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues | Signal Transduction (4.9e-04) Signaling by ERBB4 (1.4e-02) |
| PTEN*† | Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase. It negatively regulates intracellular levels of phosphatidylinositol-3,4,5- trisphosphate in cells and functions as a tumor suppressor by negatively regulating AKT/PKB signaling pathway | Signal Transduction (4.9e-04) Signaling by SCF-KIT (1.2e-02) Signaling by ERBB4 (1.4e-02) Signalling by NGF (4.6e-02) |
|||||
| ATXN1† | Chromatin-binding factor that repress Notch signaling in the absence of Notch intracellular domain by acting as a CBF1 corepressor. | none | |||||
| BMPR2*† | Member of the bone morphogenetic protein (BMP) receptor family of transmembrane serine/threonine kinases. The ligands of this receptor are BMPs, which are members of the TGF-beta superfamily. | Signal Transduction (4.9e-04) | |||||
| KAT2B* | Functions as a histone acetyltransferase (HAT) to promote transcriptional activation. Inhibits cell-cycle progression. | Signal Transduction (4.9e-04) | |||||
| PRMT5 | Protein arginine methyltransferase 5. Plays a role in the assembly of snRNP core particles. May play a role in cytokine-activated transducion pathways. Negatively regulates cyclin E1 promoter activity and cellular proliferation. | Signal Transduction (4.9e-04) | |||||
| SOCS1 | Suppressor of cytokine signalling. SOCS1 is involved in negative regulation of cytokines that signal through the JAK/STAT3 pathway. | Signaling by SCF-KIT (1.2e-02) | |||||
| TGFBR2*† | Transforming growth factor, beta receptor II. Transmembrane protein that has a protein kinase domain, forms a heterodimeric complex with TGFBR1, and binds TGF-beta. This receptor/ligand complex phosphorylates proteins, which then enter the nucleus and regulate the transcription of a subset of genes related to cell proliferation. | Signal Transduction (4.9e-04) | |||||
| BCL2L11 | Transforming growth factor, beta receptor II. Transmembrane protein that has a protein kinase domain, forms a heterodimeric complex with TGFBR1, and binds TGF-beta. This receptor/ligand complex phosphorylates proteins, which then enter the nucleus and regulate the transcription of a subset of genes related to cell proliferation. | Signalling by NGF (4.6e-02) | |||||
Biclusters containing co-targeting on KAT2B. The function of genes is extracted from GeneCards. (*) genes present in bicluster 6-72-22-70. (†) new suggested potential targets of miR-25 and miR-32.