Table 3.
Clinical and hematologic manifestation of hemoglobin H disease
| Clinical manifestation | Deletional | Nondeletional |
|---|---|---|
| Hemoglobin (g/dL) | 8.5 (range, 6.9–10.7) | 7.2 (range, 3.8–8.7) |
| MCV (fL) | 54.0 (range, 46.0–76.0) | 65.2 (range, 48.7–80.7) |
| MCH (pg) | 16.6 (range, 14.3–24.7) | 18.6 (range, 14.8–24.8) |
| Anemia | Microcytic | Normocytic |
| Reticulocytosis | + | ++ |
| Hypochromia | ++ | + |
| Age at first transfusion (yr) | 11 ± 5.5 | 1.5 ± 2.1 |
| History of blood transfusion (%) | 3–29 | 24–80 |
| Splenomegaly | + | +++ |
| Gallstones | + | ++ |
| Growth retardation | Rare | Common |
| Decreased bone density | Rare | Common |
Data from Vichinsky 2009.
MCH, mean corpuscular hemoglobin; MCV, mean corpuscular volume.