Figure 2. Knockdown of MOG1 expression by siRNAs significantly decreased INa density in HEK/Nav1.5 cells.
A. Raw traces of sodium currents. B. Effects of siRNA1 on the current- voltage relationship of Nav1.5. The current amplitudes were normalized to cell capacitance (pA/pF, abscissa). C. Effects of siRNA1 on steady-state activation (Right) and inactivation (Left) of Nav1.5. D. Effects of siRNA1 on recovery from inactivation of Nav1.5.